摘要
目的观察海南萝芙木根水溶性物质的急性毒性。方法分别采用尾静脉注射和经口灌胃进行给药实验观察实验小鼠对海南萝芙木根水溶性物质的急性毒性表现。结果尾静脉注射过量的海南萝芙木根水溶性物质后小鼠会出现一定的中毒现象,其半数致死量LD50=294.2 mg/kg。而采用灌胃给药方式毒性较小,其最大耐受量为3 445 mg/kg。结论海南萝芙木根水溶性物质口服给药不发生急性毒性反应。
Objective To observe the acute toxicity of water-soluble substance from roots of Rauvolfia verticillata Lour.Baill.Var.hainanensis Tsiang.Methods Research on acute toxicity of the water-soluble substance via intravenous injection and intragastric injection in mice were carried out.Results The mice showed a little toxicity after intravenous injection of the water-soluble substance,LD50=294.2 mg/kg.But no toxicity for the intragastric injection group,and its maximum tolerated dose was 3445 mg/kg.Conclusion In intragastric injection,the water-soluble substance from Roots of Rauvolfia verticillata Lour.Baill.Var.hainanensis Tsiang showed no sign of toxicity in mice.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2011年第4期869-871,共3页
Lishizhen Medicine and Materia Medica Research
基金
国家"863"高技术研究发展计划项目(No.2007AA021500)
海南省自然科学基金项目(No.309001)
关键词
海南萝芙木
急性毒性
水溶性物质
Rauvolfia verticillata Lour.Baill.Var.hainanensis Tsiang
Acute toxicity
Water-soluble substance