摘要
目的探讨颅内节细胞胶质瘤(gangliogliomas,GG)的组织学特征、免疫表型、诊断和鉴别诊断。方法系统分析海军总医院病理科35例GG临床资料、形态学和免疫组织化学标记。结果肿瘤大部分位于颞叶,组织学上表现为肿瘤性胶质细胞和发育不良的节细胞两种成分,伴微钙化、淋巴细胞浸润和嗜酸小体形成。免疫组化胶质成分表达GFAP、Olig-2和S-100,而节细胞表达Syn、NF、NeuN、MAP2abc和CgA。Ki-67增殖指数为1.1%,94%的GG表达CD34。结论 GG为生长缓慢的良性肿瘤,属WHOⅠ级,大部分位于幕上,尤其是颞叶和额叶。主要根据组织学和免疫组织化学进行诊断,正确诊断对患者进行适当治疗和预后判断具有十分重要意义。
Purpose To study the histological characteristic,immunophenotype,diagnosis and differential diagnosis of intracal gangliogliomas(GG).Methods The clinical data,morphology and immunohistochemistry were systematically reviewed in a series of 35 GGs which collected from the department of pathology of Navy General Hospital in China.Results The majority of these tumors occured within the temporal lobe and revealed a biphasic histological architecture characterized by a combination of neoplastic glial cell and dysplastic neurons elements.There were more microcalcifications,lymphocytic infiltration,and eosinophilic bodies.The glial component showed immunoreactivity with glial fibrillary acidic protein,Olig-2 and S-100 protein.Neuronally differentiated cells were immunolabeled by antisynaptophysin,NF,NeuN,MAP2abc and chromogranin A antibodies.The MIB-1(Ki-67) labeling index was 1.1 %,and 94% of GG revealed positive immunostaining for the stem cell marker CD34.Conclusions GGs are usually benign slow-growing neoplasms corresponding to WHO grade I,and are prevalently located supratentorial,mostly in the temporal and frontal lobe.Its diagnosis mainly depends on histopathological and immunohistochemical features.Immunohistochemical studies are an important tool to discriminate these neoplasms from other tumor entities.The accurate diagnosis is important to ensure that patients receive adequate therapy and prognostic information.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2011年第10期1055-1058,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
节细胞胶质瘤
临床病理
免疫表型
鉴别诊断
ganglioglioma
clinical papthology
immunophenotype
differential diagnosis