摘要
目的探讨心肌酶谱联合肌钙蛋白检测在甲状腺功能减退症诊断中的临床意义。方法选择2008年1月～2010年12月在我院经治疗的50例甲状腺功能减退症患者(观察组),分别检测心肌酶谱门冬氨酸氨基转移酶(AST)、肌酸磷酸激酶(CPK)及其同工酶(CPK-MB)、乳酸脱氢酶(LDH)和肌钙蛋白(CtnI)血清浓度。比较其和正常对照组的差异以及在治疗前后的变化情况。结果在治疗前,AST、CPK、CPK-MB、LDH、CtnI和正常对照组比较,差异具有统计学意义(P<0.05)。治疗后,AST、CPK、CPK-MB、LDH及CtnI与治疗前差异亦具有显著差异性,而与正常对照组比较,差异无统计学意义(P>0.05)。结论在甲状腺功能减退症患者中,AST、CPK、CPK-MB、LDH、CtnI明显升高,而在治疗后恢复,提示AST、CPK、CPK-MB、LDH、CtnI可作为疾病诊断及鉴别诊断的标准,并且可以作为治疗效果评定的指标。
Objective To explore the clinical significance of myocardial enzymes and Cardiac Troponin I in the diagnosis of hypothyroidism. Methods Selected 50 cases of hypothyroidism patients from Jan 2008 to December 2010 treated in our hospital （ observation group ）. Detected thyroid function respectively including the serum concentrations of myocardial enzyme including aspartate aminotransferase （ AST ）, creatine phosphokinase （ CPK ） and its isoenzymes （ CPK-MB ）, lactate dehydrogenase （ LDH ） ; and Cardiac Troponin I （CtnI）. Compared the differences between it and the normal control group and the changes of before and after treatment. Results Before the treatment, the comparison of AST, CPK, CPK-MB, LDH and CtnI with normal control group had a statistically significant （P 〈 0.05 ）. In comparison, before and after the treatment of AST, CPK, CPK - MB, LDH and CtnI had significant difference （P 〈 0.05 ）, and compared with control group, had no significant difference （P 〉 0.05 ）. Conclusion In hypothyroidism patients diagnosis, the indicators such as AST, CPK, CPK - MB, LDH and CtnI have significant increases, they are all recovered after treatment. AST, CPK and CPK-MB and LDH CtnI can serve as a standard for the diagnosis and differential diagnosis, the illness can serve as indicators of therapeutic effect evaluation.
出处
《中国现代医生》
2011年第30期60-61,共2页
China Modern Doctor
