摘要
目的:探讨急性髓系白血病(AML)细胞表面抗原表达与预后的关系。方法:回顾性分析90例初治AML患者,流式细胞仪检测骨髓白血病细胞表面抗原的表达情况,按染色体危险分层分为好、中、差3组,χ2分析骨髓白血病细胞表面抗原阳性率的差异;Kaplan-Meier生存分析和COX回归分析骨髓白血病细胞表面抗原的阳性率与患者预后的关系。结果:CD11b与染色体危险分层相关,单因素及多因素分析显示CD11b表达阳性是AML预后不良的独立危险因素。结论:白血病细胞表面抗原检测有助于AML预后的判断,CD11b表达阳性患者预后不良。
Objective：To incestigare the relationship between the expression of cell surface antigen and acute myeloid leukemia（AML）.Method：Retrospective study was performed on 90 denovo AML patients.Cell surface antigen was detected on bone marrow blasts by flow cytometry.Patients were classified into three groups according to the cytogenetic data.Clinical parameters were analyzed using χ^2 test and survival using Kaplan-Meier method and Cox regression.Result：CD11b was related to high-risk cytogenetic abnormalities.Univariate and multi-variate analysis indicated that CD11b-positive patients presented with decreased survival rate.Conclusion：The positive expression of CD11b was associated with the poor prognosis in AML.
出处
《临床血液学杂志》
CAS
2011年第5期520-522,共3页
Journal of Clinical Hematology
关键词
白血病
髓系
急性
细胞表面抗原
预后
leukemia
myeloid
acute
cell surface antigen
prognosis
