摘要
目的:探讨消骨增贴的质量标准。方法:用薄层色谱法鉴别消骨增贴中的马钱子、川黄柏和大黄;检查乌头碱含量;用双波长薄层扫描法对制剂中士的宁进行定量分析。结果:薄层色谱鉴别专属性强,分离度好。乌头碱限量检查不超过0.4 mg/贴,定量分析中士的宁点样量线性范围为0.61～3.05μg(r=0.998 0,n=5),平均回收率为100.73%,RSD=1.90%(n=6)。结论:所建立的方法可靠、准确、专属性强,可控制该制剂的质量。
Objective： To explore the quality standards of Xiaoguzeng Patch. Methods： Semen Stryehni, Cortex Phellodendri Chinensis, Rhizoma et Radix Rhei Officinalis in Xiaoguzeng Patch were identified by TLC, the contents of Aconitine were analysed, the contents of Strychnine in Xiaoguzeng Patch were analysed quantitatively by dual wavelength scan- ning. Results： The TLC had a good specific and separation. The content limit to Aconitine had not more than 0.4 mg/ patch. Quantitative analysis of Strychnine in the volume of sample linear range was 0.61-3.05 μg （r=0.998 0, n=5）, the average recovery was 100.73%, RSD=1.90% （n=6）. Conclusion： The method is reliable, accurate and specific. It can control the quality of the preparation.
出处
《中国医药导报》
CAS
2011年第31期81-82,共2页
China Medical Herald
