摘要
目的:探讨女性口腔扁平苔藓(OLP)与抑郁以及血清性激素、皮质醇水平之间的相关性。方法:将67例在口腔科门诊就诊的女性OLP患者按病情分为糜烂组(25例)和非糜烂组(42例),并将在同时期就诊的非口腔黏膜病变的其他良性口腔疾病设为对照组(30例)。采用焦虑自评量表(SAS)、抑郁自评量表(SDS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、生活事件量表(LES)进行焦虑、抑郁状况评定,并按DSM-IV诊断标准筛查抑郁症患者;同时测量清晨空腹血清性腺激素(FSH、LH、E2、T、PRL)和皮质醇(CORT),并将结果按月经同期或绝经期分别进行比较。采用SPSS10.0软件包对数据进行卡方、t检验及Spearman秩相关分析。结果:糜烂组病例中,10例(40%)符合DSM-IV抑郁症诊断,非糜烂组和对照组则各有6例(14.3%)和1例(3.3%)符合。糜烂组和非糜烂组的SAS、SDS、HAMA、HAMD分值和CORT水平高于对照组(P<0.05),但糜烂组和非糜烂组间无显著性差异。糜烂组LES分值高于非糜烂组和对照组,但后两者之间无显著性差异。糜烂组和非糜烂组的总生活事件分值及负性生活事件分值与SAS、SDS、HAMA、HAMD分值呈正相关。糜烂组E2、T水平低于非糜烂组和对照组(P<0.05),非糜烂组亦低于对照组,但无统计学差异。糜烂组SDS、HAMD分值与E2和T测定值之间均有相关性(P<0.05)。结论:抑郁在女性糜烂型OLP发生、发展中扮演着重要角色,性激素紊乱可能是其作用机制之一,应激则起到始动作用。对糜烂型OLP,尤其合并抑郁的女性患者,适当应用雌激素治疗将有助于病情的缓解。
PURPOSE： To explore the relationship among oral lichen planus（OLP）,depression and gonadal hormones in female patients with OLP.METHODS： Sixty-seven cases of female out-patients with OLP were divided into erosion group（n=25）and non-erosion group（n=42）.Meanwhile,30 female out-patients with other benign oral lesion and without oral mucosa diseases were used as control group.Self-rating anxiety scale（SAS）,self-rating depression scale（SDS）,Hmiton anxiety scale（HAMA）,Hmiton depression scale（HAMD） and life event scale（LES） were evaluated in all participants who were tested simultaneously with FSH,LH,E2,T,PRL as well as CORT and were screened with DSM-IV criteria for major depression.The data were analyzed by Chi-square test,Student＇s t test and Spearman rank correlation using SPSS10.0 software package.RESULTS：Ten cases（40%）met the DSM-IV diagnosis of depression in the erosion group,and 6（14.3%）,1（3.3%）in the non-erosion group and control group,respectively.The scores of SAS,SDS,HAMA,HAMD and the level of CORT in both the erosion and non-erosion groups were higher than those in the control group,but there was no significant difference between the erosion group and the non-erosion group.The score of LES in the erosion group was higher than the non-erosion group and control group,and there was no significant difference between the non-erosion group and control group.The total and negative life event scores of LES were positively correlated with the scores of SAS,SDS,HAMA and HAMD.The level of E2 and T in the erosion group was lower than the non-erosion group and control group.There was a negative correlation between the scores of SDS,HAMD and the level of E2 and T in the erosion group.CONCLUSIONS： Depression plays an important role in the development of OLP,and one mechanism may be gonadal hormone disturbance,with stress as the triggering factor.The estrin treatment is helpful to improve the treatment effect on OLP of erosion style,especially,for female patient with dep
出处
《上海口腔医学》
CAS
CSCD
2011年第5期548-552,共5页
Shanghai Journal of Stomatology
关键词
口腔扁平苔藓
抑郁
性激素
皮质醇
女性
Oral lichen planus
Depression
Gonadal hormones
Cortisol
Female
