摘要
目的:探讨牙龈低度恶性肌纤维母细胞肉瘤的临床病理特征。方法:对2例发生于14岁和16岁病人的低度恶性肌纤维母细胞肉瘤的临床病理特点进行研究,其中包括肿瘤的生长方式、细胞密度、核异型性和核分裂象。对石蜡包埋组织进行免疫组织化学检测和电镜观察。结果:大体观察,肿瘤大小为2.5～3.0 cm,呈结节状生长,边界不清,切面实性灰白或灰褐色。光镜下肿瘤细胞为梭形,呈束状排列;胞质丰富,呈嗜酸性;胞核两端尖细呈波浪状,可见小核仁。电镜下瘤细胞具有肌纤维母细胞的超微结构特点。免疫组织化学检测显示瘤细胞表达平滑肌肌动蛋白、肌动蛋白结合蛋白和纤维连接蛋白。两患者均作了肿瘤切除,术后11至15个月肿瘤局部复发。结论:牙龈低度恶性肌纤维母细胞肉瘤呈浸润性生长,瘤细胞形态温和,术后复发率高。
Objective To determine the clinicopathologic features of low-grade myofibroblastic sarcoma（LGMS） of gingiva.Methods LGMS samples from 2 cases of LGMS patients（at 14 and 16 years old,respectively） were collected.The growth pattern,cellularity,nuclear atypia,and mitotic figures of LGMS were studies.The paraffin-embedded tissue samples from the tumors were stained immunohistochemically and examined by electron microscope.Results Macroscopically,the size of tumor was range from 2.5 to 3.0 cm and showed nodular patterns,ill-defined borders,and tan or white cut surface.Microscopically,2 tumors showed slender spindle tumor cells in fascicle pattern.The tumor cells possessed abundant eosinophilic cytoplasm,wavy and tapering nuclei,and small nucleoli.Under the electron microscope,the tumor cells showed the ultrastructural features of myofibroblasts.Immunohistochemically,the spindle tumor cells were diffusely positive for SMA,calponin,and fibronectin.Local tumor resection was performed on 2 patients and local recurrences were occurred in 2 patients from 11 to 15 months after the operation.Conclusion LGMS of gingiva shows an infiltrative growth pattern and exhibits mild histologic appearance with high rate of tumor recurrence.
出处
《国际病理科学与临床杂志》
CAS
2011年第5期389-393,共5页
Journal of International Pathology and Clinical Medicine
