摘要
过去的研究认为糖皮质激素(glucocorticoids,GC)具有免疫抑制和抗炎的作用,能抑制淋巴细胞的增殖和树突状细胞的成熟,促进嗜碱粒细胞、嗜酸粒细胞和T细胞的凋亡等,故在临床上作为抗炎药和免疫抑制剂广为使用。然而临床研究日益发现,GC并不能缓解和改善缺血性脑中风、创伤性脑损伤及脑出血等引起的炎症,有时反而还会加重病情[1]。
Glucocorticoids are necessary for stress response and universally used as anti - inflammatory agents. However, recent studies indicate that glueocortieoids not only enhance the pro - inflammatory effect of stress in the brain but also aggravate brain inflammation when glucocortieoid level is chronically elevated or abnormally increased. In addition, inflammatory response has detrimental effects on the repair of injury in the hrain and contributes to several neuropsychiatric diseases. Accordingly, the capacity of glueocorticoids to augment inflammation in the brain deserves further investigation for effective clinical attenuation of brain inflammation. In this paper, we review recent advances in the characteristics and the possible mechanisms of the pro - inflammatory effect of glucocortieoids in the brain.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2011年第10期2030-2034,共5页
Chinese Journal of Pathophysiology
基金
江苏省"青蓝工程"资助项目
关键词
糖皮质激素类
脑
炎症
应激
Glucocorticoids
Brain
Inflammation
Stress
