摘要
目的:对肝豆状核变性致骨关节损害的各种症状、体征、X线检查、骨碱性磷酸酶(BAP)水平进行观察,并对驱铜治疗及配合钙剂和活性维生素D制剂治疗后BAP水平进行统计研究。方法:实验组48例患者统计骨关节损害临床症状情况,全部行相应部位X片检查。另设20名健康志愿者为健康对照组,两组均用ELISA法检验BAP。于常规驱铜治疗加钙剂和活性维生素D制剂治疗,2个月后再次检验BAP,并进行治疗前后及与健康对照组的数值统计对比。结果:BAP活性测定对HLD致骨关节损害诊断具有更好的特异性、灵敏性、准确性。结论:针对HLD骨关节病变的发病原因尽量早期采取有效驱铜治疗及配合钙剂和活性维生素D制剂治疗,可以有效预防骨关节损害进展和缓解症状,以改善HLD患者的生活质量。
Objective：To observe clinic manifastation,X-ray change, bone alkaline phosphatase（BAP） of osteoartieular damage on hepatolenticular degeneration,and analysis the variation of BAP after deeopper therapy accompanied by calsium supplement and activated vitamin D.Methads：All 48 patients m experimental group,analysis the clinic manifastation,all 48 patients are examined by X-ray.20 volunteers in matched group.BAP in two groups are examined by ELISA.BAP are examined again after deeopper therapy accompanied by calsium supplement and activated vitamin D for two month.The stasitcal data of two groups and before and after treatment is contastive analysised,.Results：The activity testing of BAP is more specific,sensitive,accurate to diagnose the osteoarticular damage on hepatolenticular degeneration.Conelusion：Decopper therapy accompanied by calsium supplement and activated vitamin D should be starts as early as possible according to the cause of osteoarticular damage on hepatolentieular degeneration,which can effeetivly prevent the evolvement of osteoarticular damage and relief the symptoms,improve the living quality of patients.
出处
《中国医药导刊》
2011年第7期1156-1158,共3页
Chinese Journal of Medicinal Guide
