摘要
目的探讨CD44+/CD24-细胞在乳腺癌细胞中的比例与乳腺癌远处转移之间的关系,研究其与各临床资料之间是否存在相关性。方法通过免疫组化双染技术,对60例病例的肿瘤石蜡切片进行分析,确定CD44+/CD24-细胞在乳腺癌细胞中所占的百分率,并分析其与远处转移之间的关系及与各项临床资料间的关系。结果 CD44+/CD24-细胞占肿瘤细胞百分比在两组中存在显著差异性,转移组中骨转移病例的CD44+/CD24-细胞在肿瘤细胞中的比例有显著性差异。结论 CD44+/CD24-细胞细胞在乳腺癌细胞中所占比例与乳腺癌远处转移密切相关,特别是骨转移。在临床病理类型,肿瘤大小,淋巴结转移情况,TNM分期,激素受体情况,肿瘤发生于绝经前后,Her-2情况中无明显差别。
【Objective】 Our study aimed to the relationship between the prevalence of CD44＋/CD24-cells in breast cancer and the distant metastasis,and also the clinical data.【Methods】 We identified CD44＋/CD24-cells by double-staining immunohistochemistry technique.We calculate and got the information of relationship of relationship between the prevalence of CD44＋/CD24-cells in breast cancer and distant metastasis,and also the clinical data.【Results】 So the difference between the prevalence of CD44＋/CD24-cells in breast cancer and the metastasis is significant.The difference of prevalence of CD44＋/CD24-cells in breast cancer in osseous metastasis is significant.【Conclusion】 The prevalence of CD44＋/CD24-cells in breast cancer is associated with distant metastasis,specially with osseous metastasis,but not with histology,tumor size,nodal status,TNM stage,menopausal status,ER,PR,or Her-2.
出处
《中国医学工程》
2011年第8期11-14,共4页
China Medical Engineering
