摘要
目的:研究分析大剂量厄贝沙坦治疗老年慢性心力衰竭(CHF)的疗效。方法:将128例老年CHF患者随机分为常规剂量组和大剂量组各64例,在同样常规治疗基础上,常规剂量组初始剂量为75mg/d,1周后加至150mg/d,后维持该剂量治疗。大剂量组初始剂量为75mg/d,1周后加倍,直到450mg/d,后维持该剂量治疗。观察分析治疗前后患者症状体征等相关指标。结果:大剂量组总有效率为96.9%,常规剂量组总有效率为78.1%,两组比较,差异具有统计学意义(P<0.01或P<0.05)。结论:大剂量厄贝沙坦治疗老年CHF安全且更为有效。
Objective： To research and analyze the efficacy of high-dose irbesartan in the treatment of chronic heart failure （CHF）. Methods： 128 elderly patients with CHF were randomly divided into two groups, based on the same conventional treatment, conventional-dose group initial dose of 75 mg/d, a week later added to 150 mg/d, unchanged after the dose. High-dose group initial dose of 75 mg/d, doubling after a week, until 450 mg/d, unchanged after the dose. The signs and symptoms in patients before and after treatment and other related indicators were observed and analyzed. Results： high-dose group, 64 patients with a total effective rate was 96.9%; conventional-dose group, the total effective rate was 78.1%. The two groups had statistical significance （P0.01 or P0.05）. Conclusion： High-dose irbesartan treatment of elderly CHF is safe and more effective.
出处
《中国当代医药》
2011年第30期37-38,共2页
China Modern Medicine
