摘要
目的评价冬病夏治消喘膏穴位贴敷疗法治疗稳定期慢性阻塞性肺疾病(COPD)的有效性和安全性。方法将142例COPD稳定期患者随机分为治疗组和对照组,每组71例;分别给予消喘膏和安慰剂贴敷治疗,1年贴治3次,连续贴敷2年。观察呼吸疾病问卷(SGRQ量表)、BODE指数、年均感冒和急性加重次数、急诊和住院次数、肺功能和皮肤刺激性等指标的变化。结果治疗组治疗1年、治疗2年与治疗前比较,SGRQ量表总分及症状、活动、影响部分评分均下降(P<0.05),除症状部分差异无统计学意义外,治疗组治疗2年活动、影响部分及总分评分较治疗1年和对照组同期下降均有统计学意义(P<0.05),治疗组优于对照组。治疗组治疗2年与治疗前、治疗1年比较BODE指数下降值大于对照组同期(P<0.01)。对照组治疗2年第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)较治疗前及治疗1年有改善(P<0.05),但与治疗组同期比较差异无统计学意义(P>0.05),治疗组治疗1年FEV1/FVC与治疗前比较下降(P<0.05)。治疗组治疗2年第1秒用力呼气容积占预计值百分比(FEV1%)与治疗1年比较有升高,但与治疗前及对照组同期比较差异无统计学意义(P>0.05)。治疗组治疗2年年均感冒和急性发作次数明显低于对照组同期,且低于本组治疗前和治疗1年时(P<0.05);治疗组治疗2年年均急诊和住院次数明显低于治疗前以及对照组同期(P<0.05)。贴敷治疗2年两组均未出现局部皮肤强烈反应,两组患者局部皮肤刺激性发生率比较差异无统计学意义(P>0.05)。结论消喘膏穴位贴敷疗法能改善稳定期COPD生存质量、减少患者急性加重,安全性较高。
Objective To evaluate the clinical effect and safety of winter disease summer treatment therapy with the application of Xiaochuan Acupoint Adhesive Plaster （Plaster applied at acupoints for stopping asthma） on chronic obstructive pulmonary disease （COPD） in stable stage. Methods Totally 142 COPD patients in stable stage were randomized into treatment group and control group with 71 in each. They were treated with the application of Xiaochuan Plaster and placebo plaster respectively, 3 times one year, 2 years in succession. The changes in St George＇s respiratory questionnaire （SGRQ） score, BODE index. The annual average times of common cold and asthma acute aggravation, times of emergency consultation and hospitalization, pulmonary function, and adverse reaction of skin were observed. Results Of the treatment group, the comparison of one-year treatment and two-year treatment with before treatment showed a decrease in the total score of SGRQ and scores of symptoms, activities, and influences （P〈0.05）, except that there was no statistical difference in symptoms, there was statistical difference in the decrease of scores of activities and influences and total score of two-year treatment in comparing with oneyear treatment and the control group in the corresponding period （P〈0. 05）. The treatment group was better than the control group. Comparing with before treatment and one-year treatment, the decreased value of BODE index in two-year treatment of the treatment group was more than that of the control group in the corresponding period （P〈0.01）. Of the control group, the ratio of the forced expiratory volume at the 1st second （FEV1） and forced volume capacity （FVC） was improved in two-year treatment as compared with before treatment and one-year treatment （P〈0.05）, however, there was no statistical difference compared with the treatment group in the eorresponding period （P〉0.05）. The FEV1/FVC was decreased in one-year treatment of the treatment group in comparing wi
出处
《中医杂志》
CSCD
北大核心
2011年第21期1831-1835,共5页
Journal of Traditional Chinese Medicine
基金
首都医学科技发展基金重点支持项目(2005-SF-II-024)
关键词
冬病夏治
消喘膏
贴敷
慢性阻塞性肺疾病
安全性
有效性
winter disease summer treatment
Xiaoehuan Acupoint Adhesive Plaster （Plaster applied at aeupoints for stopping asthma）
acupoint adhesive treatment
chronic obstructive pulmonary disease
safety
efficacy
