摘要
目的分析和研究近视性的高度屈光参差眼屈光参数及角膜生物学参数的差异性。方法对23名近视性的高度屈光参差患者（双眼等效球镜SE差≥6．00D），用眼反应分析仪（OcularResponseAn—alyzer，ORA）测量角膜滞后性（CornealHyteresis，CH），用改进的光学相干断层扫描仪（OCT-3）测量中央角膜厚度（CCT），用IOL—Master测量角膜曲率（meanK）及眼轴长度（AL）。统计处理采用配对t检验和多元线性回归分析。结果近视程度高度眼平均AL（28．34±1．10）mm，低度眼平均AL（24．53±0．70）mm，差异有统计学意义（P〈0．01）。双眼角膜平均曲率K差异无统计学意义（P〉0．05）。双眼CCT差异无统计学意义（P〉0．05）。近视程度高度眼CH平均值（10．00±1．61）mmHg，低度眼CH平均值（10．96±1．38）mmHg，双眼CH差异有统计学意义（P〈0．01）；高度眼CH与眼轴和角膜厚度相关（P〈0．05）。结论相同基因及环境下，高度近视眼的CH显著下降，角膜无明显变薄，提示眼轴的过度增长可能会导致角膜的微观结构改变，引起角膜的生物力学性能改变。
Objective To investigate the differences of refractive index and corneal biological parameter in high myopic anisometrop＇ia. Methods Twenty three subjects who suffered anisometropia （spherical equivalent ≥6.00 D） were selected. For each subject, corneal hysteresis （CH） was measured by ORA （Ocular Response Analyzer）, central corneal thickness （CCT） was measured by OCT, average keratometer value （mean K） and ocular axial length （AL） were measured by Zeiss IOL-Master, the results were tested by paired t-test and multiple linear regression. Result The differences of mean K, CCT for two eyes were not significant （P 〉0.05）. Mean AL was （28.34± 1.10） mm （SD） in high myopic eyes compared with （24.53± 0.70） mm in the fellow eye, the difference was statistically significant （P 〈0.0001）. The mean hysteresis in high myopic eyes and the fellow eyes was （10.00± 1.61） mmHg and （10.96± 1.38） mmHg, respectively; the difference was statistically significant （P 〈0.0001）. The relationship between CH and AL and CCT was statistically significant （P 〈0.05）. Conclusions Under the same gene and environment, the corneal hysteresis value is significantly lower in high myopia, which has no thinner cornea. It may be due to the change in cornea microstructure as a result of axial abnormal elongation.
出处
《中国实用眼科杂志》
CSCD
北大核心
2011年第10期1014-1017,共4页
Chinese Journal of Practical Ophthalmology
