摘要
目的探讨18F—FLTPET／CT显像在鼻咽癌诊断、分期和预后中的临床价值。方法13例鼻咽癌患者行18F—FLTPET／CT显像，其中1例患者也行18F-FDGPET／CT显像。通过软件自动获得病灶ROI的SUVmax和SUVmean。分析18F—FLTPET／CT显像病灶SUV与病理类型、分期及预后的关系，并进行1例患者的18F—FLT和“F—FDGPET／CT显像对比。结果13例鼻咽癌患者鼻咽部位高摄取18F—FLt灶22处，SUVmax为6．04±3．61，SUVmean。为5．09±2．89；淋巴结转移灶26处，SUVmax。为5．56±3．11，SUVmean。为4．65±2．79。18F＋Fu显像中鼻咽癌原发灶及淋巴结转移灶均能清晰显影。行2种显像的1例患者所有病灶18F—FLT显像的SUV较18F—FDG显像低：1处原发灶SUVmax分别为8．32和4．38，2处淋巴结转移灶SUVmax为3．30±0．07和1．48±0．06。13例鼻咽癌患者的TNM分期在进行18F—FLTPET／CT显像后有3例发生了改变。结论”F—FLTPET／CT显像能清晰显示鼻咽癌原发病灶及转移病灶，对确定患者TNM分期有临床应用价值。
Objective To evaluate the usefulness of tSF-FLT PET/CT imaging in detecting and staging nasopharyngeal carcinoma （NPC）patients. Methods Thirteen patients with NPC underwent whole- body lSF-FLT PET/CT imaging, one of which underwent whole-body ISF-FDG PET/CT imaging one day earlier. SUVmax and SUV from lSF-FLT andlSF-FDG imaging were obtained using circular ROI in primary and metastasis lesions and were compared with the results of histopathology. The staging results by ts F-FLT PET was compared with those by CT. Results The SUVmaxcand SUV obtained from 18 F-FLT imaging in 22 nasopharyngeal sites in 13 patients were 6.04 ＋ 3.61 and 5.09± 2.89, and the SUVmax and SUV in 26 lymphadenopathy were 5.56 ± 3.11 and 4.65 ± 2.79. is F-FDG SUVmax were higher than is F-FLT SUV in one primary lesion （8.32 vs 4.38） and two lymph nodes （3.30 ±0.07 vs 1.48 ±0.06） in the patient who underwent the two imagings. Compared with CT staging results, the TNM stage in 3 patients had been changed based on ISF-FLT PET/CT imaging. Conclusions High radioactivity of primary and second le- sions can be detected on lSF-FLT imaging in patients with NPC and lSF-FLT PET/CT imaging may be useful in staging for NPC.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2011年第5期306-309,共4页
Chinese Journal of Nuclear Medicine
基金
江苏省普通高校研究生科研创新计划项目
