摘要
目的探讨慢性特发性荨麻疹患者血清细胞因子水平测定的临床意义。方法随机选择慢性特发性荨麻疹患者48例,健康检查的正常人48例,分为两组,分别测定其血清中IL-2、4、6、8、10、12及IFN-γ的含量。结果慢性特发性荨麻疹患者组血清中IL-4、IL-8水平显著高于正常对照组(P<0.01);IL-6、IL-10水平略高于对照组,但差异无统计学意义(P>0.05);IL-2、IL-12、IFN-γ水平明显低于正常对照组(P<0.01)。结论慢性特发性荨麻疹患者血清IL-2、IL-4、IL-8、IL-12及IFN-γ水平异常,提示慢性特发性荨麻疹的发病与免疫相关。
Objective To explore detection of serum cytokines levels in patients with chronic idiopathic urticaria and the clinical implication. Methods The serum levels of IL-2, IL-4, IL-6, IL-8, IL-10, IL-12 and IFN-γwere determined by ELISA in 48 Patients with chronic idiopathic urticaria and 48 normal controls. Results the levels of IL-4 and IL-8 were significantly higher than those in normal controls （P〈0. 01 ）. The levels of IL-6 and IL-IO were slightly higher than those in normal controls, but there was no significant difference （P〉0.05） ; while the level of IL-2, IL-12 and IFN-γ were significantly lower than those in normal controls（P〈0. 01 ）. Conclusion Chronic idiopathic urticaria may be associated with immune defense mechanism by means of the abnormal level of IL-2, IL-4, IL-6,IL-8, IL-10, IL-12, and IFN-γin patients with chronic idiopathic urticaria.
出处
《皮肤病与性病》
2011年第5期255-257,共3页
Dermatology and Venereology
关键词
慢性特发性荨麻疹
白介素
干扰素
检测
临床意义
Chronic idioputhic urticaria
Interleukin
Interferon
Detection
Clinical significance
