摘要
目的探讨不同代谢综合征（MS）诊断标准与中老年人心脑血管病（CCVD）患病的关系。方法于2009年在北京城区、近郊区平原和远郊山区对55岁及以上中老年人进行调查和检查，共1458名中老年人完成问卷调查和实验室检查。分别采用世界卫生组织（WHO）定义、美国国家胆固醇教育计划成人治疗组第3次报告（NCEP—ATPⅢ）修订定义、国际糖尿病联盟（IDF）定义和中华医学会糖尿病分会（CDS）定义计算MS患病率，分析MS患病与CCVD患病的关系。结果无论采用何种定义，MS患者CCVD、脑卒中、冠心病患病危险均明显高于非MS者，WHO定义、NCEP-ATPⅢ修订定义、IDF定义和CDS定义的MS者CCVD危险均明显增加，其中WHO定义和CDS定义的MS与CCVD患病的关联程度最高，这2种定义的MS患者CCVD患病的危险分别是非MS者的2．14倍（OR=2．14，95％CI：1.59～2．87）和1．91倍（OR=1．91，95％CI：1．43～2．55），而NCEP—ATPⅢ修订定义和IDF定义的MS患者CCVD患病的危险分别是非MS者的1．68倍（OR=1．68，95％CI：1．32～2．15）和1．64倍（OR=1．64，95％CI：1．26～2．13）。采用Logistic回归模型控制年龄、性别、地区、吸烟和饮酒史后，上述4种定义所计算的OR值分别是1．91、1．88、1．67、1．80。分别分析上述4种MS定义与脑卒中和冠心病患病的危险，结果依然显示WHO定义和CDS定义的MS与这2种疾病的关联程度最高。结论采用WHO定义和CDS定义的MS是反映55岁及以上中老年人CCVD患病危险的最佳指标。
Objective To study the association of prevalence of cardio-cerebro vascular diseases （CCVD） with metabolic syndrome （MS） defined by different criteria in middle and aged people. Methods A cross section survey was conducted among 1458 people aged 55 years and over in urban and rural areas of Beijing in 2009. MS definitions by World Health Organization （WHO）, National Cholesterol Education Program-Adult Treatment Panel Ⅲ （NCEP-ATP Ⅲ） revised, international diabetes mellitus （IDF） and Chinese Diabetes Society （CDS） were applied to analyze the association MS with the prevalence of CCVD. Results The risks of CCVD were all significantly higher in patients with MS than with non-MS using 4 definitions of MS. The definitions of WHO and CDS showed well agreement with the prevalence of CCVD. OR values of MS for CCVD were 2.14 folds （95% CI： 1, 59-2.87） for WHO definition and 1, 91 folds （95% CI： 1.43-2.55） for CDS definition, while OR values of MS for CCVD were 1.68 folds （95% CI： 1.32-2.15） for NCEP ATPI]] definition and 1.64 folds （95M CI： 1.26-2.13） for IDF definition as compared to non-MS, respectively. After adjustment for age, sex, region, history of smoking and alcohol drinking, the OR values in above four definitions were 1.91, 1.88, 1.67 and 1.80, respectively. The OR value of MS was highest for stroke by CDS definition and highest for coronary heart values defined by WHO and CDS are the optimal people. disease by WHO definition. Conclusions MS index of prevalence for CCVD in middle and aged
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2011年第10期871-875,共5页
Chinese Journal of Geriatrics
基金
国家自然科学基金项目（8107236]）
关键词
代谢综合征X
卒中
冠心病
Metabolic syndrome X
Stroke
Coronary disease
