摘要
目的观察清肝宁肺方对嗜酸粒细胞性支气管炎(Eosinophilic bronchitis EB)致慢性咳嗽肝火犯肺证的疗效,寻求中西医治疗EB的新方法及其机制。方法 60例EB中医辨证肝火犯肺患者,随机分为两组各30例,治疗组予服用清肝宁肺方,对照组吸入普米克气雾剂。疗程1个月。治疗前后记录咳嗽症状、咳嗽相关生活质量、分析诱导痰细胞学。结果治疗组和对照组咳嗽症状总有效率分别为93.3%和86.7%,两组比较差异无统计学意义(P>0.05);治疗后诱导痰嗜酸粒细胞比例转为正常者治疗组21例(70.0%),对照组13例(43.3%),两组比较差异有统计学意义(P<0.05);两组对咳嗽相关生活质量总有效率分别为93.3%和73.3%,两组比较差异有统计学意义(P<0.05)。治疗期间治疗组未发现有副作用者;对照组有2例患者出现咽喉轻度不适。结论清肝宁肺方与普米克气雾剂均可改善EB患者临床症状,但抑制EB的气管炎症、提高咳嗽相关生活质量治疗组优于对照组,且其副作用较普米克气雾剂少。
Objective To observe curative effects of Qinggan Ningfei decoction on eosinophilic bronchitis（EB） in syndrome of liver-fire attacking lung and investigate the new therapy of Chinese and western medicine and its action mechanism on EB.Methods 60 patients with EB in liver-fire attacking lung type were randomly divided into treament group and control group,30 patients in each group.The patients in treatment group were treated with Qinggan Ningfei decoction and in control group with pulmicort aerosol,one month a treatment course.Before and after the treatment,the symptom of cough,quality of life effected by cough and analysis of induced sputum cytology were recorded.Results The total effective rates for cough in treatment group and control group were 93.3% and 86.7% respectively（P〉0.05）;The 21 patients（70.0%） in treatment group induced sputum eosinophils to normal,while the13 patients（43.3%） in control group only（P〈0.05）.The total effective improving rate of the life quality related by cough in treatment group and control group were 93.3% and 73.3% respectively（P〈0.05）.During the treatment period,there no side effects to be found in treatment group,but two patients felt mild discomfort in throat in control group.Conclusion Both Qinggan Ningfei decoction and Pulmicort aerosol can improve clinical symptoms of EB,but Qinggan Ningfei decoction is more effective to inhibit inflammation of trachitis and increase the life quality.
出处
《湖南中医药大学学报》
CAS
2011年第9期61-63,67,共4页
Journal of Hunan University of Chinese Medicine
