摘要
目的探讨BCR-ABL融合基因阳性的急性混合细胞白血病的特点及其可能原因。方法对2例BCR-ABL融合基因阳性的急性混合细胞白血病患者的临床资料、细胞形态学、流式细胞仪免疫分型结果及荧光原位杂交术进行分析,并结合文献进行复习。结果文献及本组病例共6例,6例患者均BCR-ABL融合基因阳性或t(9;22)(q34,q1l)即Ph染色体阳性;3例慢性粒细胞白血病急变为BCR-ABL融合基因阳性的急性混合细胞白血病,3例无慢性粒细胞白血病病史,初发诊断为BCR-ABL融合基因阳性的急性混合细胞白血病;4例双系列型,1例双表型,1例系列转换型。结论初发的BCR-ABL融合基因阳性的急性混合细胞白血病鲜有报道,部分病例由慢性粒细胞白血病急变而来。
Objective To investigate the features and causes of acute mixed lineage leukemia that expressed BCR/ABL fusion gene by fluorescence in situ hybridization （FISH）. Methods The clinical data,the morphological analysis of bone marrow cells,and flow cytometer （FCM） of two cases were analyzed and related literatures were reviewed. Results In six cases of acute mixed line- age leukemia with BCR/ABL fusion gene, three cases were primary diagnosed with BCR/ABL＋ acute mixed lineage leukemia in which other medical history information did not found, while another three cases were diagnosed with acute mixed lineage leukemia which were found as chronic myeloid leukemia（CML） before. Conclusion It is rarely reported that primary diagnosed with BCR/ ABL＋ acute mixed lineage leukemia. Some cases of chronic myeloid leukemia maybe change to acute mixed lineage leukemia by blast crisis.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第30期3024-3026,共3页
Chongqing medicine
基金
国家自然科学基金资助项目(30971109)
重庆市自然科学基金资助项目(CSTC2009BA5011)
