摘要
目的探讨帕瑞昔布钠复合丙泊酚麻醉用于无痛人工流产术的镇痛效果和安全性。方法 120例美国医师协会(ASA)分级Ⅰ或Ⅱ级门诊无痛人工流产术患者,随机分为A、B两组,每组60例。B组术前15min帕瑞昔布钠40mg静脉注射,两组均给予丙泊酚2mg/kg静脉注射,术中根据患者体动反应追加丙泊酚至体动反应消失。观察术前、术中、术后的MAP、HR与丙泊酚用药总量、术后苏醒时间、术后30min宫缩疼痛VAS评分及恶心呕吐、头晕、嗜睡、皮肤瘙痒、呼吸抑制、异常出血等不良反应。结果与A组比较,B组丙泊酚的用药总量明显减少(P<0.05),呼吸抑制的发生率减少(P<0.05);术后30min宫缩疼痛VAS评分B组优于A组(P<0.01),而不良反应没有增加。结论帕瑞昔布钠复合丙泊酚用于无痛人工流产术,可减少丙泊酚的用量和呼吸抑制的发生,增强镇痛效果而不增加不良反应。
Objective To investigate the efficacy and safety of artificial abortion combined anesthesia using parecoxibna and ropofol. Methods The 120 out-patients （ ASA I - II ）required induced abortion of indolence randomly divided into group A and group B, with 60 cases in each group. Group B was injected parecoxibna 40 mg 15 minutes before operation, ropofol was given in accordance with body action until it disappeared in the operation. MAP, HR, total dosage of propofol, awake time after operation, VAS scores of womb reducing pain 30 minutes after operation, adverse reactions such as nausea, vomiting, dizziness, lethargy, pruritus, respiratory depression and abnormal bleeding were observed. Results Compared with group A, the total drug of propofol of group B significantly reduced （P 〈 0.05 ） ; The incidence of respiratory depression of group B reduced （P 〈 0.05 ） ; Contractions pain VAS score of Postoperative 30 min was better in group B than in group A （P 〈 0.01 ）, but no adverse reactions increased. Conclusion Parecoxib sodium and propofol for painless abortion can reduce the amount of propofol and the occurrence of respiratory depression, and enhance the analgesic effect without increasing side effects.
出处
《中国现代医生》
2011年第29期87-88,共2页
China Modern Doctor
关键词
帕瑞昔布钠
丙泊酚
人工流产术
镇痛
Parecoxib sodium
Propofol
Induced abortion
Analgesic
