摘要
目的研究终末期肾脏病（ESRD）透析患者血清抵抗素（Resistin）水平及其与超敏C-反应蛋白（hs—CRP）、肿瘤坏死因子仅（TNF—d）、血清白蛋白（Alb）、血脂等的关系。方法选择ESRD透析患者144例，分为血液透析组（96例）和腹膜透析组（48例），另设正常对照组（40例）。用ELISA方法检测血清Resistin、hs—CRP和TNF-α，同时常规测定血清白蛋白（Alb）、血总胆固醇（Tc）和甘油三酯（TG），分析Resistin与这些血清因子的相关性。结果（1）透析患者血清Resis—tin水平：血液透析组（15．20±3．22）ng／ml，腹膜透析组（11．12±2．02）ng／ml，对照组（5．53±1．86）mg／L，差异均有统计学意义（P〈0．01）。（2）相关性分析：血液透析患者Resistin与hs—CRP（r=0．359，P〈0．01）、TNF-α（r=0．487，P〈0．05）、TG（r=0．015，P〈0．05）成正相关，与Alb（r=-0．255，P〈0．05）成负相关；腹膜透析患者Resistin与hs—CRP（r=0．224，P〈0．05）、TNF-α（r=0．220，P〈0．01）、TC（r=0．055，P〈0．05）、TG（r=0．042，P〈0．05）成正相关，与TC（r=-0．201，P〈0．05）成负相关。结论在终末期肾脏病，无论血液透析、腹膜透析患者，其Resistin均明显升高，并与hs—CRP、TNF-α、Alb、TC、TG检测结果有关，提示Resistin可能对ESRD透析患者的微炎症起一定作用。
Objective To examine the levels of serum resistin in dialysis patients with end stage renal disease （ESRD）, and investigate the relationship between serum resistin and high sensitivity C - reactive protein （ hs - CRP）, tumor necrosis factor -α （TNF -α） , albumin, blood lipid. Methods 144 dialysis patients with end stage renal failure and 40noimal healthy persons were involved in this study. The patients were divided into two groups ： patients with hemodialysis （ HD, 96 cases ） and patients with peritonealdialysis（PD,48cases）. The levels of serum resistin, hs -CRP, TNF-α were detected by means of ELISA. The levels of serum albumin, cholesterol（TC） , triglyceride （TG） were detected by conventional methods. Results The levels of serum resistin were significantly higher in dialysis patients [ HD （ 15.20 ± 3.22 ） ng/ml, PD （ 11.12 ± 2.02） ng/ml ] than those in healthy subjects [ （5.53 ±1.86）mg/L], （P 〈 0. 01 ）. The levels of serum resistin were significantly higher in PD patients than those in HD patients. Correlation analysis indicates ： Serum resistin levels in HD patients were positively related to serum hs - CRP（ r = 0. 359, P 〈 0. 01 ） ） , TNF -α （ r = 0. 487, P 〈 0. 05 ） , and TG （ r = 0. 015, P 〈 0. 05 ） , and negatively related to serum Alb （ - 0. 255, P 〈 0. 05 ）. Serum resistin levels in PD patients were positively related to serum hs -CRP（r =0. 224,P 〈0. 05 ）, TNF-α（ r =0. 220,P 〈 0. 01 ）, TC（r =0. 055,P 〈0. 05 ）, TG（r =0. 042,P 〈 0. 05）, and negatively related to serum Alb（r = -0. 201,P 〈 0. 05 ）. Conclusions The levels of serum resietin is markedly increased in dialysis patients with ESRD. In addition, the study demonstrates the relationship betreen serum resistin and TNF -α, hs - CRP, Alb, TC, TG levels and suggestes that resistin might play a role in the sub -clinical inflammation associatet with ESRD.
出处
《浙江临床医学》
2011年第10期1091-1093,共3页
Zhejiang Clinical Medical Journal
关键词
终末期肾脏病
透析
抵抗素
微炎症
血脂
End stage renal disease Dialysis Resistin Microinflammation Blood lipid
