摘要
[目的]观察中青年人冠心病危险因素的分布状况,为中青年早期防治冠心病提供依据.[方法]选择本院2007年1月至2010年6月中青年冠心病住院患者（年龄≤59岁）80例作为观察组,以按1：2比例随机抽取的相匹配的中青年非冠心病住院患者160例作为对照组,用单因素分析和多因素条件logistic回归分析探讨高血压、吸烟史、体重指数（BMI）、糖尿病、冠心病家族史、血清胆固醇（TC）、血清甘油三酯（TG）、血清高密度脂蛋白胆固醇（HDL-C）等传统危险因素对中青年患者患冠心病的相对危险度.[结果]单因素显示吸烟史、BMI、冠心病家族史、TC、TG、HDL-C两组间有统计学差异（P〈0.01或P〈0.05）.logistic 回归显示吸烟史（OR值为1.7431,95 %CI：089～3.125） 、TC（OR值为11.342,95 %CI：3.012～40.467）、冠心病家族史（OR值为6.577,95%CI：2.761～27.569）是使中青年患者冠心病的相对危险度增加的独立影响因子（P〈0.01,P〈0.05）.[结论]中青年人冠心病主要危险因素是吸烟、血清高胆固醇、冠心病家族史.改变不良生活方式、对高危人群进行干预可能有助于早期防治中青年冠心病.
[Objective] To observe the distribution of risk factors in middle-age and young patients with coronary heart disease（CHD） in order to provide the evidence for the early prevention and cure of CHD in middle-age and young adults. [Methods] Totally 80 middle-age and young hospitalized patients with CHD（aged under 59 years old） from Jan. 2007 to June 2010 were selected as the observation group. According to the matched ratio of 1 to 2, other 160 middle-age and young hospitalized patients without CHD were randomly selected as the control group. Univariate analysis and multivariate logistic regression analysis were used to analyze the relative risk of traditional factors such as hypertension, the history of smoking, body mass index（BMI）, diabetes, the family history of CHD, serum choles- terol（TC）, triglyceride（TG） and high density lipoprotein cholesferol to the incidence of CHD in middle-age and young adults. [Results] Univariate analysis showed that there was significant difference in BMI, the history of smoking, TC, TG and HDL-C between two groups（ P 〈0.05）. Multivariate logistic regression analysis showed that the history of smoking（ OR=1. 7431, 95 %CI：089-3. 125）, TC（OR=11. 342, 95%CI：3. 012-40. 467） and the family history of CHD（OR= 6. 577, 95 % CI： 2.761- 27. 569） were the independent risk factors resulting in the increasing of relative risk of CHD in middle-age and young adults. [Conclusion] Smoking, high level of serum TC and the fami ly history of CHD are the main risk factors of CHD in middle-age and young adults. The modification of unhealthy life style and the intervention of high-risk population may be helpful for the early prevention and cure of CHD in middle-age and young adults.
出处
《医学临床研究》
CAS
2011年第9期1722-1724,共3页
Journal of Clinical Research
