摘要
目的:优化1,4-二氯酞嗪的合成工艺,提高反应收率。方法:以邻苯二甲酸酐为原料,经缩合和氯代反应合成目标化合物。结果:改进了合成工艺,总收率提高到85.0%。合成的化合物结构均经HRMS和1H-NMR确证。结论:改进后的合成工艺,操作简化,产品质量提高,成本降低,该工艺切实可行,适合工业化生产。
Objective： To optimize synthetic process of 1,4-dichlorophthalazine and to increase the yield.Methods： The target compound was synthesized from phthalic anhydride by condensation and chlorination reaction.Results： The synthetic process was improved,and the overall yield was increased to 85.0%.The structure of the synthetic compound was identified by HRMS and 1H-NMR.Conclusion： After the improvement synthesis process,the operation is simplified,the product quality is enhanced and the cost is decreased,the improvement synthesis process is feasible and practicable to the industrialization production.
出处
《中国医药导报》
CAS
2011年第29期55-56,共2页
China Medical Herald
基金
郑州大学大学生创新性实验计划项目基金资助(项目编号:101045903)
关键词
1
4-二氯酞嗪
合成
缩合反应
氯代反应
1
4-dichlorophthalazine
Synthesis
Condensation
Chlorination
