摘要
目的探讨辛伐他汀对中老年高血压患者颈动脉粥样硬化的影响。方法将在本院接受治疗的90例颈动脉粥样硬化斑块患者随机分成治疗组和对照组各45例,治疗组服用辛伐他汀20mg/晚,对照组行其他非辛伐他汀药物治疗,进行为期6个月的观察对比。结果治疗组治疗后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)水平显著下降,高密度脂蛋白(HDL)水平显著升高(P<0.01),颈动脉内膜-中层厚度(IMT)、斑块面积变小,与治疗前比较差异有统计学意义(P<0.05)。结论辛伐他汀能稳定和消退粥样斑块,调脂疗效确切,从而减少心脑血管事件的发生。
Objective To investigate the effects of simvastatin in elderly hypertensive patients with carotid atherosclerosis.Methods In the hospital treated 90 cases of carotid atherosclerotic plaques were randomly divided into treatment group and control group each 45 patients,the treatment group received simvastatin 20mg/night,control group of other non-drug treatment simvastatin for a period of 6 months,observation compared.Results After treatment,total cholesterol（TC）,triglyceride（TG）,low density lipoprotein（LDL） levels decreased significantly,high-density lipoprotein（HDL） levels were significantly increased（P〈0.01）,neck artery intima-media thickness a（IMT）,plaque area smaller,compared with before treatment.Difference was statistically significant（P〈0.05）.Conclusions Simvastatin can stabilize and plaque regression,lipid-lowering efficacy obvious,thereby reducing cardiovascular events.
出处
《医药论坛杂志》
2011年第17期76-77,共2页
Journal of Medical Forum
