摘要
探讨核素肾动态显像和尿微量白蛋白检测对早期发现糖尿病肾病的临床意义。收集了内科诊断为II型糖尿病为主的住院病人60例,选择临床上无糖尿病和和高血压诊断的对照组20例,两组进行系列常规检查,并做同位素肾图检查来测定肾脏的肾小球滤过率(GFR),按病人的GFR测定值分为增高(>120 mL/min)、正常(70–120 mL/min)、降低(<70 mL/min)组。这些糖尿病人中高GFR者占8.33%(5/60),平均为141.98±13.60mg/min,比对照组增高35%,差异非常显著(P<0.01);GFR正常者占33.33%(20/60),平均为102.18±10.24mg/min,与对照组相比差异无显著性(P>0.05);GFR降低者占58.33%(35/60),平均为57.19±18.00 mg/min,比对照组降低54.3%,差异非常显著(P<0.01);同时三组病人的尿微量蛋白与对照组相比差异非常显著性(P<0.01)。结果显示,对于糖尿病患者定期联合检测尿微量白蛋白、尿β2-微球蛋白尿和GFR不仅有助于糖尿病肾病的早期诊断,而且还有助于糖尿病肾病的疗效监控和预后判断。
To investigate clinical value of glomerular filtration rate （GFR） and urine microalbumin in early diagnosis of diabetic nephropathy, GFR in 60 patients with type II diabetes mellitus and a control group of 20 were determined using 99TcmDTPA renal dynamic imaging and urine microalbumin. The following results were obtained. Among the 60 patients with diabetes, 5 patients had increased GFRs of, 142.0± 13.6mg/min, which was 35% higher than that of controls and differed significantly from the control （P〈0. 01）; 20 patients had GFRs of 102.2± 10.2mg/min, which differed little from the control; and 35 patients had declined GFRs of 57.2± 18.0mg/min, which was 54.3% lowered than the control and differed significantly from the control （P〈 0.01）. The urine microalbumin in diabetes patients was significantly higher than the control. In conclusion, the GFR is a good index of the early kidney injury in diabetic patients. The combined detection of GFR and urine microalbumin can improve the early diagnosis of diabetic nephropathy, and may help to monitor the treatment response and assess prognosis.
出处
《核技术》
CAS
CSCD
北大核心
2011年第10期777-780,共4页
Nuclear Techniques
关键词
Ⅱ型糖尿病
糖尿病肾病
肾小球滤过率
尿微量白蛋白
Type 2 diabetes, Diabetic nephropathy, Glomerular filtration rate, Urine microalbumin
