摘要
目的以亲水-亲脂平衡值为指标考察精制蛋黄卵磷脂在水中和油中的分散特性并研究其在鸦胆子油乳注射液中的应用。方法采用核磁共振波谱(NMR)法,根据其化学位移值及亲水基团与亲油基团质子数相对比值(R)计算亲水-亲脂平衡值。结果精制蛋黄卵磷脂在水中具有良好的分散性。结论可用精制蛋黄卵磷脂代替豆磷脂作乳化剂制备鸦胆子油乳注射液。
Objective To investigate the dispersion characteristics of refined egg lecithin in water or oil with hydrophile-lipophile balance（HLB） as the index and to study its application in Brucea Javanica Oil Emulsion Injection.Methods Using nuclear magnetic resonance spectroscopy（NMR）,based on their chemical shift differences and the relative ratio（R） of protons number in hydrophilic groups and lipophilic groups,HLB value was calculated.Results The refined egg lecithin had better dispersibility in water.Conclusion The refined egg lecithin can replace the soybean lecithin as emulsifier for preparing Brucea Javanica Oil Emulsion Injection.
出处
《中国药业》
CAS
2011年第20期21-23,共3页
China Pharmaceuticals
关键词
精制蛋黄卵磷脂
亲水-亲脂平衡值
核磁共振波谱法
鸦胆子油乳注射液
refined egg lecithin
hydrophile-lipophile balance（HLB）
nuclear magnetic resonance spectroscopy（NMR）
Brucea Javanica Oil Emulsion Injection
