摘要
目的探讨血清脂联素、超敏C反应蛋白(hs-CRP)水平变化与糖尿病前期发生的危险因素的关系。方法选取健康对照组(NGT)、糖耐量减低组(IGT)、空腹血糖受损合并糖耐量减低组(IFG/IGT)各100例,测定各受试者血清脂联素、hs-CRP、空腹胰岛素、空腹血糖、餐后2 h血糖,应用稳态模型评估法评价胰岛素抵抗。结果 IGT组、IFG/IGT组血清脂联素均显著低于NGT组(P<0.01),IFG/IGT组的脂联素水平低于单纯IGT组(P<0.05)。脂联素水平与空腹血糖、餐后2 h血糖、胰岛素抵抗指数(HOMA-IR)呈负相关(P值均小于0.01)。单纯IGT组、IFG/IGT组血清hs-CRP水平明显高于NGT组(P<0.01),IFG/IGT组血清hs-CRP水平高于单纯IGT组(P<0.05)。血清hs-CRP水平与空腹血糖、餐后2 h血糖、HOMA-IR呈正相关(P值均小于0.01)。结论血清脂联素、hs-CRP可能是加重糖尿病前期胰岛素抵抗的危险因素,糖调节受损期即可能存在慢性低度炎症反应。在糖尿病前期,脂联素、hs-CRP可能参与了糖尿病的发生及发展。
Objective To investigate the association between risk factors of pre-diabetes and the changes of serum adiponectin and hs-CRP levels.Methods The healthy control group（NGT,n=100）,impaired glucose tolerance group（IGT,n=100）,impaired fasting glucose group（IFG） and the combined impaired glucose tolerance（IFG/IGT,n=100） were set and 100 samples from each group were tested.The concentrations of fasting serum adiponectin,hs-CRP,FINS,FBG,PBG were detected.Insulin resistance（IR） index was estimated by using HOMA.Results The concentrations of serum adiponectin in IGT groups,IFG/IGT groups were obviously decreased compared with those in NGT groups（P0.01）.The concentrations of serum adiponectin in IFG/IGT were obviously decreased compared with those in IGT groups（P0.05）.The correlation analysis showed that the concentrations of serum adiponectin were negatively correlated with FBG,PBG,HOMA-IR（all P0.01）.The concentrations of serum hs-CRP in IGT groups,IFG/IGT groups were obviously increase compared with those in NGT groups（P0.01）.The concentrations of serum hs-CRP in IFG/IGT groups were obviously increase compared with those in IGT groups（P0.05）.The correlation analysis showed that the concentrations of serum hs-CRP were positively correlated with FBG,PBG,HOMA-IR（all P0.01）.Conclusion The concentrations of serum adiponectin,hs-CRP might be the risk factors of HOMA-IR in pre-diabetes patients.Chronic low inflammation response might exist in impaired glucose tolerance groups.The concentration changes of serum adiponectin,hs-CRP in pre-diabetes patients might be involved in the pathogenesis and the development of diabetes.
出处
《检验医学与临床》
CAS
2011年第19期2305-2306,共2页
Laboratory Medicine and Clinic
