摘要
目的:探讨"三高"(高血压、高脂血症、高血糖)患者发生脑血管意外后,机体氧化及抗氧化能力的变化关系及其机制。方法:检测125例典型"三高"患者血清超氧化物歧化酶(SOD)和丙二醛(MDA)水平,分析脑血管事件与上述指标的关系,并与健康对照组比较。结果:与健康对照组(CNⅠ组)及未发生脑血管事件的"三高"对照组(CNⅡ组)比,脑出血组(CH组)和脑梗死组(CI组)SOD含量无显著性差异(P>0.05),但均有降低趋势;脑出血组和脑梗死组之间无显著性差异(P>0.05(。与CNⅠ组及CNⅡ组比,CH组和CI组MDA含量均明显升高(P<0.05),CH组和CI组之间无显著性差异(P>0.05)。CNⅠ组与CNⅡ组相比无明显差异,但存在增减趋势。结论:检测血清SOD和MDA含量的变化有助于对脑血管疾病患者的诊断及病情观察。
Objective： To study the relationship and mechanism of oxidation and antioxidant capacity between normal persons and cerebrovascular diseases patients who had suffered from hypertension,hyperlipemia or diabetes.Methods： Serum MDA and SOD of 125 patients suffering from hypertension,hyperlipemia or diabetes were tested to analyze the relationship between cerebrovascular diseases and the indicators,then compared with healthy control group.Results： Compared with healthy control group（CNⅠ） and no cerebrovascular diseases group（CNⅡ）,the indicators of cerebral hemonhage group（CH） and cerebral infarction group（CI） were different.For CH and CI,MDA increased significantly（P〈0.05）,SOD differed not much（P〉0.05）,but SOD showed lessening tendency.MDA showed no significance between cerebral hemonhage and cerebral infarction patients（P〉0.05）.Between patients with hypertension,hyperlipemia or diabetes and normal persons,each item was not different,but for the former,SOD was lower and MDA was higher.Conclusion： Serum SOD,MDA and its change may be reference to morbidity,diagnosis and observation of the diseases state.
出处
《中国医药导报》
CAS
2011年第28期186-188,共3页
China Medical Herald
基金
河北省科学技术研究与发展指导计划项目(062761569)
