摘要
目的基于症状学探讨胃食管反流病（GERD）和喉咽反流病（LPRD）的关系。方法对2007年8月至2010年10月来北京大学人民医院动力室检查的患者，采用反流疾病问卷（RDQ）和反流症状指数（RSI）调查，RDQ积分≥12分诊断为GERD；RSI积分≥13分认为存在LPRD。共向1090例患者发放问卷，有效问卷895份。其中女474例，平均年龄（54±13）岁，男421例，平均年龄（52±14）岁。结果895例患者无反流性疾病者351例，仅有GERD者237例，仅有LPRD者89例，二者同时具有218例，3组的年龄、性别构成比等差异均无统计学意义（P=0．383、0．227）。GERD患者中同时患有LPRD患者47．9％（218／455）；而LPRD患者中同时有GERD者达71．0％（218／307）。在GERD患者中，反食频率及反食程度与RSI积分相关（r=0．115、0．141，P：0．007、0．001）。结论ERD和LPRD可以共存，也可以单独存在，其机制有待进一步研究；但单独的LPRD仅占少数，GERD的治疗策略可能需要调整；GERD患者合并反食症状，一定程度提示喉咽反流的可能性。
Objective To explore the relationship between gastroesophageal reflux disease （GERD） and laryngopharyngeal reflux disease （LPRD） based on symptoms. Methods A total of 1090 patients undergoing upper digestive tract motility test were invited to complete the surveys of reflux disease questionnaire and reflux symptom index from August 2007 to October 2010. And 895 responders provided valid answers. There were 474 females and 421 males. Results Among 895 responders, 351 patients had neither, 218 suffered both conditions, 237 were diagnosed as GERD alone and 89 LPRD alone. No difference was found in age （ P = 0. 383 ） or gender ratio （ P = 0. 227 ）. In 455 GERD patients, there were 218 LPRD cases （47.9%）. In 307 LPRD patients, 218 （71.0%） had concurrent GERD. In GERD patients, the frequency and degree of feeling of stomach content reflux into mouth were correlated with RSI （ r = 0. 115, 0. 141, P =0. 007, 0. 001 ）. Conclusion GERD and LPRD may coexist or occur alone. Because of a high concurrent ratio of LPRD in GERD, the treatment strategy of GERD should be modified accordingly. In GERD patients, the feeling of stomach content reflux into mouth may suggest a possibility of LPRD.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2011年第35期2472-2475,共4页
National Medical Journal of China
关键词
胃食管反流
问卷调查
喉咽反流
Gastroesophageal reflux
Questionnaires
Laryngopharyngeal reflux
