摘要
目的探讨大剂量盐酸氨溴索防治新生儿呼吸窘迫综合征(NRDS)的临床效果及安全性.方法 91例早产儿被随机分为两组,对照组45例给予综合治疗;治疗组46例在此基础上给予盐酸氨溴索,7.5mg/kg,静脉注射,次/6 h,连用7 d.结果治疗组患儿NRDS的发生率较对照组低(15%与40%),呼吸窘迫消失的时间〔(77.6±9.1)h与(83.3±10.5)h〕、氧疗时间〔(69.2±7.6)h与(74.2±8.9)h〕及住院时间〔(12.5±2.9)d与(14.7±3.4)d〕明显较对照组短,且差异均有统计学意义(P<0.01).结论盐酸氨溴索对预防和治疗NRDS有明显的临床效果,值得临床推广应用.
Objective To investigate the clinical efficacy and safety of ambroxol hydrochloride in preventing and treating neonatal respiratory distress syndrome（NRDS）.Methods 91 premature infants were divided into two groups randomly.45 premature infants in control group were preformed with combined therapy.On this basis,46 cases in treatment group were given ambroxol hydrochloride,7.5 mg/kg,intervenous drop infusion,once every six hours,the course of treatment was 7 days.Results The incidence of NRDS in the treatment group was lower than that in the control group（15%vs 40%）.The respiratory distress relief time,oxygen time and the lengths of hospitalization in the treatment group were shorter than those in the control group（（77.6±9.1）h vs（83.3±10.5）h;（69.2±7.6）h vs（74.2±8.9）h;（12.5±2.9）d vs（14.7±3.4）d,respectively）,there was a significant difference（P0.01）.Conclusion Ambroxol hydrochloride has significant clinical effects in prevention and treatment of NRDS,and deserves to generalize in clinic.
出处
《昆明医学院学报》
2011年第7期120-123,共4页
Journal of Kunming Medical College
关键词
新生儿
早产儿
呼吸窘迫综合征
盐酸氨溴索
Neonate
Premature infant
Respiratory distress syndrome
Ambroxol hydrochloride
