摘要
目的 观察醛固酮拮抗剂在慢性心力衰竭治疗中的应用.方法 选择符合慢性心力衰竭诊断标准的患者106例,随机分为治疗组56例和对照组50例.对照组应用慢性心衰的常规治疗;治疗组除应用常规治疗外每天服用螺内酯20~40mg,并且长期应用,定期测定血清钾和肝、肾功能,随访两年.结果 治疗组56例因心衰恶化反复住院18例（占32%）,死亡14例（占25%）;对照组50例因心衰恶化反复住院26例（占52%）,死亡21例（占42%）.χ2=4.3,P＜0.05,两组对比差别有显著性.结论 慢性心力衰竭的患者在常规治疗的基础上加用醛固酮拮抗剂,可以防止心肌纤维化的加重,改善心功能.
Objective Observe the effect of aldosterone antagonists in the treatment of CHF. Methods Select 106 patients who accord with the diagnostic critei＇ia of CHF, randomly divide the therapia group （56） and control group （50）, the control group apply the conventional theapy of CHF; thetherapia group apply spironolactone, 20-40mg/day and long-term application, except the conventional therapy. Periodically mensurate serum potassium/liver andrenal function, follow-up two years. Results There are 18 repeated hospitalization eases （32%） and 14 death cases （25%） in thetherapia group because of the deterioration of heart function, however, 26 repeated hospitalization cases （52%） and 21 death cases （42%） in the control group. x2=4.3, P〈0.05, the result show significance. Conclusions The application of aldosterone antagonists may prevent the aggravation of myocardial fibrosis and improve heart function in the base of conventional therapy of CHF.
作者
王世英
WANG Shi-ying（The people＇s Hospital of Biyang Country of Henan Province, Biyang 463700, China）
出处
《医学信息》
2011年第19期6393-6394,共2页
Journal of Medical Information
关键词
慢性心力衰竭
醛固酮拮抗剂
Chronic cardiac failure
Aldosterone antagonists
