摘要
目的:探讨尿激酶动脉溶栓治疗急性脑梗死的临床疗效和安全性。方法:对照组31例急性脑梗死患者根据病情给予相应的对症治疗;观察组31例急性脑梗死患者起病至溶栓时间3～24h(颈内动脉系统闭塞6h内,椎基底动脉系统闭塞24h内),在对症治疗基础上予尿激酶行动脉溶栓治疗,观察血管再通率,比较两组神经功能缺损程度评分及疗效。结果:观察组31例患者闭塞血管影像学再通率为87.1%;经72h、2周治疗后,两组神经功能缺损程度评分比较差异有统计学意义(P<0.01);治疗2周后,观察组总有效率(90.32%)明显高于对照组(61.29%),差异有统计学意义(P<0.01)。结论:尿激酶动脉溶栓治疗急性脑梗死疗效显著,患者闭塞血管再通率高,神经功能缺损恢复早,改善预后,是脑梗死的有效治疗手段。
Objective： To investigate the clinical efficacy and safety of intra-arterial thrombolysis with urokinase for acute ischemic cerebral infarction. （AICI）. Methods： 31 patients of AICI in 3-24 h （carotid artery occlusion in 6 h, the vertebrohasilar occlusion within 24 h） were treated by intra-arterial thrombolysis with urokinase. Recanalization rate, neurologic impairment score were observed and compared. Results： The recanalization rate of observation group was 87.1%. After treatment, the There was significant difference in neurologic impairment score between two groups（P〈0.01）. Total effective rate in observation group（ 90. 32%） was significantly higher than that in control group（61.29%）（P〈0.01）. Conclusion： Intra-arterial thrombolysis with urokinase has significant effect and high recanalization rate. This treatment provide an early neurological deficit recovery and can improve prognosis. So it＇s an effective treatment of cerebral infarction.
出处
《海南医学院学报》
CAS
2011年第11期1472-1475,共4页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110404)~~
关键词
尿激酶
动脉溶栓
脑梗死
Urokinase
Arterial thrombolysis
Cerebral infarction
