摘要
目的对IIIB-T4期非小细胞肺癌(NSCLC)患者的预后相关因素进行探讨,比较干性IIIB期与湿性IIIB期患者生存相关因素及在预后方面的差异。方法回顾性分析未手术的IIIB-T4期NSCLC患者共141例。结果单因素分析表明患者的功能状态评分(ECOGPS)、淋巴结转移情况、治疗前血红蛋白、胸腔积液或(及)心包积液、白蛋白,化疗周期数与NSCLC患者生存期有关。干性IIIB期即未合并胸腔积液或(及)心包积液组患者中位生存时间为15.10个月,1年生存率为17%,湿性IIIB期即合并胸腔积液或/及心包积液组患者为8.27个月,1年生存率为11%(=0.013)。多因素分析显示ECOG PS评分、胸腔积液或/及心包积液、白蛋白,化疗周期数及对患者的生存有统计学意义(均<0.05)。结论湿性IIIB期即合并胸腔积液/心包积液是NSCLC患者差的预后表现。ECOG PS评分、白蛋白,化疗周期数是影响ⅢB-T4期NSCLC预后的相关因素。
Objective To investigate the prognostic factors in patients with non-small cell lung cancer（NSCLC） at stage IIIB-T4 and to compare survival related factors and difference of prognostic factors between dry IIIB and wet IIIB patients.Methods Retrospective study was carried on 183 patients who suffered from non-small cell lung cancer without operation Results Kaplan-Meier analysis showed that ECOG PS,lymph nodes status,hemoglobin before treatment,pleural effusion,pericardial effusion,albumin and chemotherapy periodicity were related to prognosis（P0.05）.Patients with dry IIIB had a medium survival time of 15.10 months,and the survival rate of 1 year was 17%.Patients with wet IIIB had a median survival time of 8.27 months,and the survival rate of 1 year was 11%（P=0.013）.Pleural effusion,pericardial effusion,albumin and chemotherapy periodicity in patients with unresectable NSCLC at stage IIIB were independent prognostic factors..Conclusions Pleural effusion/pericardial effusion is the poor prognostic factor in NSCLC.ECOG PS score,albumin and chemotherapy periodicity are the related factors which can impact the prognosis of NSCLC patients at stage ⅢB-T4.
出处
《现代实用医学》
2011年第8期852-855,共4页
Modern Practical Medicine
关键词
非小细胞肺癌
ⅢB期
胸腔积液
预后
Non-small cell lung cancer
Stage IIIB
Pleural effusion
Prognosis
