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穿透素-3(PTX-3)的研究现况 被引量:11

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摘要 穿透素家族(PTXs)是参与炎症急性期和免疫应答反映过程保守蛋白中的一个亚家族。人PTX-3基因定位于第3号染色体q25区内,LPS、IL—1和TNF—α等促炎症因子可以诱导内皮细胞、单核细胞以及心肌细胞表达PTX-3。研究表明,PTX-3作为一种呵溶性模式识别受体在先天性免疫反应中具有重要作用,其亦属于炎症急性期反应蛋白,与机体免疫功能、感染性疾病和冠状动脉粥样硬化性心脏病(CHD)等疾病的发生发展密切相关。现就PTX-3的生物学特征,功能和临床研究现况作一综述。
机构地区 山东大学医学院
出处 《山东医药》 CAS 北大核心 2011年第35期115-116,共2页 Shandong Medical Journal
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二级参考文献9

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共引文献4

同被引文献75

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