摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者凝血纤溶的变化及其在临床中的意义。方法选择OSAHS患者38例及健康对照组22例,采用血凝仪检测患者及对照组静脉血凝血酶原时间(PT)、部分凝血活酶时间(APTT)、国际标准化比值(INR)、血浆纤维蛋白原(FIB)、D-二聚体的水平。结果 OSAHS组与正常组相比,PT、APTTI、NR缩短,FIB及D-二聚体升高(P<0.05)。结论 OS-AHS患者存在凝血纤溶状态的变化,可能是OSAHS患者易合并心脑血管血栓性疾病的重要因素。
Objective： To detect the diversities of blood clotting,fibrinolytic status and their clinical significances in obstructive sleep apnea hypopnea syndrome（OSAHS）.Methods： There were 38 patients with OSAHS,and 22 normal controls.The prothrombin time（PT）,partial thromboplastin time（APTT）,international standardized ratio（INR）,plasma fibrinogen（FIB） and D-dimer were detected.Results： The PT,APTT and INR activity degraded more in the OSAHS patients than those in the normal controls（P0.01;P0.05）,but blood FIB and D-dimer increased more in the OSAHS patients than in the normal controls（P0.01）.Conclusion： There are diversities of blood clotting and fibrinolytic status in OSAHS patients,which are important factors about of heart-cerebral vessel embolism diseases.
出处
《泰山医学院学报》
CAS
2011年第7期489-491,共3页
Journal of Taishan Medical College
基金
泰安市科技发展计划项目(20103026)
