摘要
目的:探讨血清甲状腺球蛋白(Tg)和131I-全身显像(131I-WBS)联合检查在分化型甲状腺癌(differentiatedthyroidcarcinoma,DTC)患者手术+131I治疗后随访中的临床价值。方法:55例DTC患者术后3～4周行131I清除残余甲状腺组织治疗(以下简称"清甲"),131I治疗前及随访时用RIA法各测定1次血清Tg,同时口服131I111～185MBq(平均133.8MBq)48h后,和(或)口服治疗剂量131I3.7～5.55GBq(平均4.5GBq)5～7d后做全身显像。结果:24例经临床证实有复发或转移的DTC患者中,11例(45.8%)Tg>10ng/mL,21例(87.5%)131I-WBS阳性,只有8例(33.3%)患者Tg和131I-WBS同时阳性。结论:DTC经手术+131I治疗后,常规进行Tg测定和131I-WBS检查,对尽早发现复发或有无转移、决策131I治疗方案以及评估131I疗效具有重要的临床价值。
Objective To investigate the clinical value of serum thyroglobulin（Tg） measurements combined with Iodine-131 （131I） whole body scans （WBS） in the follow-up of differentiated thyroid carcinoma （DTC） after thyroid ablation.Methods Fifty-five patients were enrolled in the study.A diagnostic 131I-WBS was performed 48h after administration of 111 ～ 185 MBq 131I in patients with post-thyroidectomy and 131I ablated treatment.Subsequently,therapeutic 131I-WBS were performed 5 ～ 7 days after administration of 3.7 ～ 5.55 GBq 131I.Serum Tg and anti-thyroglobulin autoantibody were measured in all patients.Results In 11 of 24 patients （45.8%） with relapsed or metastatic differentiated thyroid carcinoma,the serum Tg values increased over normal range.In 21 patients （87.5%）,the results of 131I-WBS were positive.Among these patients,both abnormally radioactive uptake in 131I-WBS and elevation of serum Tg were found in only 8 patients （33.3%）.Conclusions Routine serum Tg measurement and 131I-WBS in patients with DTC after thyroidectomy is essential.It is of great clinical value in early detecting metastatic nidus,optimizing the treatment protocol and evaluating the curative effect.
出处
《实用医学杂志》
CAS
北大核心
2011年第19期3505-3507,共3页
The Journal of Practical Medicine
基金
广西医疗卫生重点科研课题(编号:重 2000985)
