摘要
Knoevenagel缩合反应被广泛应用于合成香料、化工原料及药物中间体。离子液体作为反应溶剂,能促使一系列醛、酮与活泼亚甲基化合物的Knoevenagel缩合反应顺利进行。功能化离子液体作为催化剂成功催化Knoevenagel缩合反应,避免了使用额外催化剂。离子液体被认为是环境友好的"绿色"溶剂和"可设计"溶剂,为Knoevenagel缩合反应提供了高效、环保的制备途径。该文综述了离子液体在Knoevenagel缩合反应中的应用进展。
The Knoevenagel condensation reaction has been widely used to prepare fragrance, chemical materials and pharmaceutical intermediates. With ionic liquids as reaction solvents, reactions of a wide range of aldehydes and ketones with methylene compounds proceed smoothly. Functional ionic liquids as catalysts can successfully catalyze Knoevenagel reactions in the absence of any other catalyst. Ionic liquids, as ＂green＂ and ＂designable＂ solvents, provide a highly efficient and environmentally friendly approach for Knoevenagel reactions. In this paper, the progress in the application of ionic liquids in Knoevenagel condensation reactions is reviewed.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2011年第10期937-940,共4页
Fine Chemicals
基金
黑龙江省人力资源和社会保障厅留学回国人员科技项目
哈尔滨市科技创新人才研究专项资金项目(留学回国项目)(2011RFLXS028)~~
