摘要
目的:从体内和体外2个试验体系检测95%氨氯吡啶酸原药的致突变性,预测其遗传危害,为其安全使用提供科学依据。方法:采用小鼠骨髓嗜多染红细胞微核试验、中国仓鼠肺细胞(CHL)染色体畸变试验方法检测95%氨氯吡啶酸原药的致突变性。结果:95%氨氯吡啶酸原药各剂量组小鼠骨髓嗜多染红细胞微核率与阴性对照组比较,差异无统计学意义(P>0.05);95%氨氯吡啶酸原药各剂量组CHL细胞染色体畸变率,在直接作用和代谢活化条件下,与溶剂对照组比较,差异均无统计学意义(P>0.05)。结论:在本试验条件下,95%氨氯吡啶酸原药无诱导小鼠骨髓细胞染色体损伤及致CHL细胞染色体畸变的作用。
Objective：To observe the mutagenicity of 95% picloram both in vivo and in vitro,and to predict its genetic damage,and so as to provide scientific basis for its safe use.Methods：Mouse bone marrow polychromatic erythrocytes（PCE） micronucleus test and chinese hamster lung cell（CHL） aberration test were used for the observation of the mutagenicity of 95% picloram.Results：There was no significant difference of micronucleus rates in mouse bone marrow PCE between groups exposed to different doses of 95% picloram and negative control group（P0.05）,and there was no significant difference of chromosomal aberration rates in CHL cells between different dose groups and solvent control group（P0.05）neither in direct effect nor in metabolic activation conditions.Conclusions：Under this experimental condition,95% picloram can not induce chromosome injury of mouse bone ma-rrow PCE or chromosomal aberration of CHL cells.
出处
《贵阳医学院学报》
CAS
2011年第4期347-350,共4页
Journal of Guiyang Medical College
关键词
农药
氨氯吡啶酸
微核
染色体畸变
小鼠
pesticides
aminopyralid
micronucleus
chromosomal aberration
mice
