摘要
目的:探索羧甲基壳聚糖(CMC)对D-半乳糖诱导氧化损伤模型小鼠肝、脑的作用。方法:实验分为4组:对照组、CMC组、D-半乳糖模型组、D-半乳糖+CMC组。测定各组小鼠肝、脑超氧化物歧化酶(SOD)、过氧化氢酶(CAT)的活性、丙二醛(MDA)的含量及蛋白质羰基化程度。结果:D-半乳糖可诱导小鼠蛋白质羰基化,诱导小鼠氧化损伤,CMC可使小鼠蛋白质羰基化含量降低,SOD、CAT活性增加,MDA含量降低。结论:CMC对D-半乳糖引起的氧化损伤有一定的保护作用。
OBJECTIVE To investigate the protective effect of CMC on the liver and brain in mice damaged by D-galactose. METHODS Animals were divided into four groups： control group;D-galactose treated animals;control＋CMC group;D-galactose＋CMC group.Protein carbonyl and SOD,CAT,MDA of the liver and brain were detected. RESULTS D-galactose induced protein carbonyl of brain and liver,CMC decreased it.CMC increased the activity of SOD and CAT and decreased the MDA content. CONCLUSION CMC might play a protective effect on the oxidative protein damage of brain and liver in mice.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第18期1514-1516,共3页
Chinese Journal of Hospital Pharmacy
基金
全军"十一五"资助项目(编号:06MA09)
