摘要
目的了解新疆维吾尔自治区伊犁哈萨克自治州布尔津县哈萨克族居民原发性高血压(EH)的遗传特征及其相关危险因素,为采取相应的干预措施提供参考依据。方法采用以医院为基础病例对照研究方法对2005年6月—2010年12月在新疆维吾尔自治区伊犁哈萨克自治州布尔津县医院就诊的270例EH患者及同期体检的420名非高血压健康人群进行EH相关因素的问卷调查及生理和生化指标检测。结果布尔津县哈萨克族EH患者遗传度为56.8%,其中男61.2%,女53.5%;病例组家系一级亲属、家系男性一级亲属和家系女性一级亲属的患病率分别为30.50%、36.12%和28.12%,均高于对照组的15.21%、16.97%和12.09%,差异有统计学意义(P<0.05);布尔津县哈萨克族EH患者分离比为0.17,符合多基因遗传病特征(分离比<0.25);多因素条件Logistic回归分析结果表明,有高血压家族史、肥胖、饮酒、高盐饮食是布尔津县哈萨克族居民患EH的主要危险因素。结论布尔津县哈萨克族居民EH患者有明显遗传倾向,具有多基因遗传特征;有高血压家族史、肥胖、饮酒过量、高盐饮食的哈萨克族居民患EH的危险性较大。
Objective To explore the genetic characteristics and risk factors of essential hypertension among Kazakh in Burqin County of Ill Autonomous Prefecture of Xinjiang Uygur Autonomous Region. Methods Totally 290 essential hypertension （EH） patients of Chinese Kazakh in Burqin were selected as case - group and 450 health individuals as control - group. The information on general condition, living style, disease history, and familial history were collected with a fcae - to - face interview among the subjects. The height, weight, waist circumference, hipcireumference, blood pressure, body fatpereentage, total cholesterel （TC）, trigiyceride （TG）, low - density lipoprotein cholesterol （ LDL - C）, high - density lipoprotein cholesterol （ HDL - C）, fasting plasma glucose （FPG）, plasma insulin, and adiponectin of the subjects were measured. All data were analyzed with SPSS16. 0 software. Multiple factor logistic regression andx^22 test were used for analysis. Results The prevalence rate of EH among fn＇st -degree relatives （30. 50% ） in EH was higher than that of in the control group （ 15.21%, P 〈 0. 05 ）. The heredity of EH among Chinese Kasakh in Burqin was 56. 8%. The seperation ratio of EH （0. 17） showed a polygenic inheritance in heredity mode. EH family history, bodymass index （BM I）, body fat rate, alcoholdrinking, salt intake were associated with EH by multiple factor logistic regression analysis. Conclusion The prevalence of EH shows an obviousl hereditary tendency and the character of polygentic disease among Chinese Kazakh in Burqin. EH family history, obesity, alochol drinking, higher intake of salt are important risk factors of EH for ChineseKorean in Yanbian area.
出处
《临床合理用药杂志》
2011年第05X期116-117,共2页
Chinese Journal of Clinical Rational Drug Use
基金
新疆维吾尔自治区中医药民族医青年人才项目(2009ZMY13)
关键词
原发性高血压
遗传特征
危险因素
Essential hypertension
Genetic characteristics
Risk factor
