摘要
目的探讨Ⅲ度羊水污染对新生儿神经系统的影响。方法胎儿宫内窘迫患儿44例,其中Ⅲ度羊水污染20例作为观察组,其余24例患儿为对照组,2组患儿出生后1 min5、min、10 min给予Apgar评分;生后72 h行头颅CT检查;生后第3天、第14天行新生儿神经行为测定(NBNA)。结果观察组1 min Apgar评分、第3天NBNA评分明显低于对照组(t=-2.55,P=0.02;t=-2.31,P=0.03),5 min Apgar评分、10 min Apgar评分、第14天NBNA差异无统计学意义(t=1.45,P=0.16;t=0.04,P=0.97;t=-0.61,P=0.55)。观察组窒息率明显高于对照组(2χ=4.14,P=0.04),头颅CT异常率高于对照组(χ2=4.40,P=0.04),观察组在行为能力方面明显低于对照组(t=-2.31,P=0.03)。结论Ⅲ度羊水污染新生儿窒息明显高于其他胎儿窘迫患儿,脑损伤发生率高,早期护脑干预可减轻脑损伤程度。
Objective To explore the effect of severe meconium stained amniotic fluid on neonatal nervous system.Methods Forty-four neonates with fetal distress were divided into severe meconium stained amniotic fluid group as study group（n=20）,and the rest as the control group（n=20）.In neonates of the two groups,1 min,5 min,10 min Apgar score,head CT after birth 72 hours,NBNA scores after birth 3 days and 15 days were analyzed.Results 1 min Apgar score and NBNA after birth 3 days of study group were lower than the control group（t=-2.55,P=0.02;t=-2.31,P=0.03）.5 min Apgar score,10 min Apgar score and NBNA after birth 14 days were different in the two groups（t=1.45,P=0.16;t=0.04,P=0.97;t=-0.61,P=0.55）.Neonatal asphyxia incidence in study group was higher than the control group（χ2=4.14,P=0.04）.The abnormal ratio of head CT in study group was higher than the control group（χ2=4.40,P=0.04）.The score of behavioral ability in study group were lower than the control group（t=-2.31,P=0.03）.Conclusion The ratio of neonatal asphyxia and brain injure in severe meconium stained amniotic fluid were obviously higher than other fetal distress neonates.Early intervention can reduce brain injury.
出处
《中国实用神经疾病杂志》
2011年第17期17-19,共3页
Chinese Journal of Practical Nervous Diseases
