摘要
目的探讨卡介菌多糖核酸、红霉素对恶性胸腔积液治疗的疗效及不良反应。方法将82例恶性胸腔积液患者分为卡介菌多糖核酸组43例和红霉组39例。卡介菌多糖核酸组采用卡介菌多糖核酸注入胸膜腔进行胸膜硬化治疗;红霉素组采用红霉素注入胸膜腔进行胸膜硬化治疗,每周1次。4周后观察其疗效及不良反应。结果卡介菌多糖核酸组总有效率为72.1%,红霉素组总有效率为74.4%,2组临床疗效比较差异无统计学意义(P>0.05);卡介菌多糖核酸组不良反应总发生率为14.0%低于红霉素组的100.0%,差异有统计学意义(P<0.05)。结论卡介菌多糖核酸治疗恶性胸腔积液的疗效与红霉素相近,但不良反应少,值得临床推广应用。
Objective To explore the effect and adverse reaction of bacillus caimette-guerin ribonucleic acid and erythromycin in patient with malignant pleral effusion.Methods 82 cases patients with malignant pleural effeusion were divided into bacillus caimette-guerin ribonucleic acid group（43 cases） and erythromycin group（39 cases）.Bacillus caimette-guerin ribonucleic acid group were treated by bacillus caimette-guerin ribonucleic acid,erythromycin group were treated by erythomycin.Results The total effective rate of bacillus caimette-guerin ribonucleic acid group was 72.1%,the total effective rate of erythromycin group was74.4%,the difference was statistically insignificant（P0.05）;Adverse reaction rate of bacillus caimette-guerin ribonucleic acid group（14.0%） was lower than that of erythromycin group（100.0%）,the difference was statistically significant（P0.05）.Conclusion The effect of bacillus caimette-guerin ribonucleic acid in malignant pleural effusion is similar to erythromycin,has less adverse reaction,is worthy of clinical application.
出处
《临床合理用药杂志》
2011年第11期20-21,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
卡介菌多糖核酸
红霉素
胸腔积液
恶性
胸膜硬化
Bacillus caimette-guerin ribonucleic acid
Erythromycin
Pleural effeusion
malignant
Pleurosclerosis
