摘要
神经突触的STDP(Spike Timing Dependent Plasticity)机制被认为是脑神经网络中最重要的机制之一,最有效的模拟STDP神经突触的方法是建立神经突触的离子通道的动力学模型。目前的STDP突触系统建模均存在一定的缺陷,不能很好地解释STDP机制的细胞分子生物反应原理或者得到STDP的时间非对称实验结果。提出一种新型的STDP神经突触系统模型,通过两个重要的输入信号用以验证该模型。仿真和验证结果表明,所提出的模型不仅反应了STDP神经突触实际的生理学机理,而且还得到STDP神经突触的时间非对称结果。
STDP （Spike Timing Dependent Plasticity） mechanism of synapses is considered to be one of the most important mechanisms of neural network, and the most effective method of emulated STDP synapse is to establishing the kinetic model of synaptic ion channels. However, most of the existing modeling of STDP synaptic mechanism have some certain defects, they either can＇t well explained the biomolecular reactions at a cellular level which is responsible for STDP, or acquired asymmetric STDP responses. A new modeling of STDP synaptic system was proposed. Two significant synaptic inputs were designed which were used to make the verification of the system. The simulation and verification results show that the new modeling not only reflects the actual physiological mechanism of STDP synapses, but also asymmetric STDP responses are obtained.
出处
《系统仿真学报》
CAS
CSCD
北大核心
2011年第10期2234-2238,共5页
Journal of System Simulation
基金
国家自然科学基金-青年科学基金项目(61006027)
关键词
突触可塑性
谷氨酸信号
后向传播树突信号
非对称结果
synaptic plasticity
glutamate signal
back propagation dendrite signal
asymmetric responses
