摘要
采用热重法和微分热重法研究药物头孢菌素类在空气流中的热稳定性和贮存期。采用Coats-Redfern法获取动力学参数,根据热分析实验数据,计算头孢菌素类热分解反应活化能E,通过活化能的比较,判断头孢菌类药物的热稳定性和预测其贮存期。结果表明,用热分析方法可以快速、科学、经济地预测药物的稳定性和贮存期。
Thermogravimetry （TG） and differential thermogravimetry （DTG） technique were applied to study the thermal stabilities and predict the shelf-time of cephalosporin in atmosphere. The kinetic parameters, activation energy E was determined by Coats- Redfern, the estimation of thermal stabilities and the forecast of shelf-time of eephalosporin was given by comparing the activation energy E. The results indicated that thermal analysis is a quick, scientifieal and economical method to study the thermal stabilities of drugs and to predict the shelf-time of drugs.
出处
《化学工程师》
CAS
2011年第9期4-7,共4页
Chemical Engineer
基金
海南大学"211"研究生创新平台科研基金项目
海南大学材料与化工学院青年基金项目
关键词
头孢菌素
热分析动力学
稳定性
贮存期
cephalosporin
thermal analysis kinetic
stability
shelf time
