摘要
以3-甲氧基-4-羟基苯甲醛(香兰素)为原料,经与盐酸羟胺反应得到3甲氧基-4-羟基苯腈,再与碱金属卤化物经脱甲基化反应合成3,4-二羟基苯腈,产品含量99.8%,以香兰素计总收率75.2%。与其他合成方法比较,这条合成路线更适合于工业化。
4-hydroxy-3-methoxybenzonitrile was prepared using vanillin as the raw material,reacted with hydroxylamine hydrochloride.Then 3,4-dihydroxybenzonitrile was synthesized form 4-hydroxy-3-methoxybenzonitrile by demethylation with metal halide.A overall yield of 75.2%and a content of 99.8%were obtained.This synthetic route is more suitable than others for industrial.
出处
《精细与专用化学品》
CAS
2011年第9期30-34,共5页
Fine and Specialty Chemicals
