摘要
目的观察左炔诺孕酮宫内缓释系统（LNG-IUS；商品名：曼月乐）对功能失调性子宫出血的临床疗效。方法对45例子宫内膜诊刮病理诊断为功能失调性子宫出血患者放置左炔诺孕酮宫内缓释系统，在放置前和放置满24个月内定期B超监测子宫内膜厚度，观察患者血红蛋白情况及月经改善情况。结果置LNG-IUS前子宫内膜厚度为（15．6±4．2）mm，置LNG-IUS24个月子宫内膜厚度为（3．2±1．3）mm，两者比较差异有统计学意义（U=2．82，P〈0．01）；放置LNG—IUS6个月后患者血红蛋白显着升高[（97．6±8．2）g／L升到（123．7±8．1）g／L]，差异有统计学意义（U=2．26，P〈0．05）。置LNG—IUS后患者出现不规则少量子宫出血或点滴出血。结论左炔诺孕酮宫内缓释系统不但能从临床方面有效地控制月经，对功血有持续的疗效，对复杂型增生的子宫内膜也有抑制作用。
Objective To evaluate the efficacy and side-effects of the levonorgestrel-releasing intrauterine device （Mirena） in the treatment of dysfunctional uterine bleeding . Methods 45 cases of dysfunctional uterine bleeding diagnosed by pathology were installed with Mirena. The endometrial thickness by uhrasound,hemoglobulin increase and pathologic changes of endometria were recorded before and 24 months after the installation. Results The endometrial thickness before and after the insertion of Mirena were（ 15.6 ± 4. 2） mm and （ 3.2 ± 1.3 ） mmrespectively （ P 〈 0. 01 ）. Six months after the insertion of Mirena, patients＇ hemoglobulin was significantly increased from （ 97. 6 ± 8.2 ） g/L to （ 123.7 ± 8.1 ） g/L （ U = 2. 26, P 〈 0. 05 ）. After the installation of Mirena, patient experienced metrorrhagia. ConclusionsMirena is a device providing effective and continual therapy for dysfunctional uterine bleeding . It can not only significantly reduce the menstrual blood loss but also reverse the complex hyperplasia effectively.
出处
《中国综合临床》
2011年第9期993-995,共3页
Clinical Medicine of China
关键词
左炔诺孕酮宫内缓释系统
功能失调性子宫出血
子宫内膜
Levonorgestrel-releasing intrauterine device
Dysfunctional uterine bleeding
Endometrial hyperplasia
