摘要
大量的研究结果显示吸烟是糖尿病发生发展的主要危险因素之一。烟草中的尼古丁可以直接损害胰岛β细胞,影响胰岛素信号转导以及炎性因子表达异常引起胰岛素抵抗,进而引发一系列糖脂代谢紊乱。吸烟加速糖尿病慢性并发症的进程,增加糖尿病大血管和微血管病变。虽然长期戒烟带来的益处超过了短期体质量改变的危害,但戒烟问题仍不容乐观,戒烟药物的有效或安全性缺乏足够的证据,糖尿病患者戒烟的课题需要进一步研究。
Numerous studies showed that smoking is a major diabetes risk factor.Nicotine in tobacco can damage β-cell,affect insulin signal transduction and inflammatory cytokine expression caused by abnormal insulin resistance,triggering a series of lipid disorders.Smoking speed up the process of chronic complications of diabetes,increased macrovascular and microvascular disease.Although the long-term benefits of quitting smoking and body mass change over the short-term harm,but the problem is still not optimistic,smoking cessation drugs effective or sufficient evidence of the lack of security,the subject of smoking cessation in patients with diabetes requires further study.
出处
《医学综述》
2011年第18期2802-2805,共4页
Medical Recapitulate
关键词
吸烟
糖尿病
糖尿病并发症
胰岛素抵抗
代谢综合征
Smoking
Diabetes
Diabetic complication
Insulin resistance
Metabolic syndrome
