摘要
目的探讨美托洛尔控制冠状动脉搭桥术中心率的效果及安全性。方法回顾性分析4｜D例不停跳冠状动脉搭桥术患者的临床资料。结果40例患者静脉注射美托洛尔1min后HR开始减慢，3min后即显著下降至（69．2±10．8）~／min，与治疗前[（85．1-i-13．5）次／min]差异有统计学意义（t=3．94，P〈0．01），10min时降到最低值（63．0±6．2）次／min，30min后缓慢上升，但仍未超过治疗前水平；术中平均动脉压相对稳定，治疗后3min、5min、10min、30min与治疗前差异无统计学意义（F=0．56，P〉0．05）。结论美托洛尔能有效控制不停跳冠状动脉搭桥术中心率变化，且不会导致血流动力学变化。
Objective To investigate the therapentic effect and safety by use of Metoprolol to control patients,heart rate in off-pump coronary artery bypass graft （OPCAB）. Methods Analyse the dates of 40 OPCABG pa- tients in anesthetic stage. Results In all of the cases,when patients were treated with venous injection of Metoprolol, the heat rate obviously decreased I minutes later （ P 〈 0.01 ）. the heat rate decreased significant to （ 69.2 ± 10.8） times/min 3 minutes later,Compared to the heat rate（85.1 ± 13.5） times/min of pretherapy there was statistical sig- nificance, the heat rate decreased to nadir（63.0 ±6.2） times/min 10 minutes later. While it raised gradnally 30 mi- nutes later, but patients＇heat rate nulli-exceed, it of pretherapy. On post-treatment of 3min,5min, 10min,30min, The MAP nulli-genic marked change. Conclusion Metoprolol could control effectively patients,heat rate in OPCAB and keep hemodynamics stable.
出处
《中国基层医药》
CAS
2011年第19期2597-2598,共2页
Chinese Journal of Primary Medicine and Pharmacy
