摘要
探讨乙型肝炎患者血浆D．二聚体（D-D）含量与肝功能储备状态的关系。方法、根据肝功能储备状态，将77例乙型肝炎患者分成肝功能代偿组44例，肝功能失代偿组33例，两组测定血浆D．二聚体、凝血酶原时间（PT）和肝功能指标。结果肝功能失代偿组患者血浆D．二聚体含量（299．0±498．5）μg/L显著高于肝功能代偿组（27．9±34．0）彬L（t=3．1，P〈0．01）；D．二聚体与血清白蛋白（ALB）和凝血酶原活动度（PA）呈显著负相关（r=-0．6、-0．6，均P〈0．01）；而与TBIL和P，r呈显著正相关（r=0．4、0．6，均P〈0．01）。结论乙型肝炎患者血浆D一二聚体水平与肝功能储备状态相关，检测D．二聚体有助于肝功能储备的评估和预后的判断。
To investigate the relationship between the level of plasma D-dimer（D-D） and hepat- ic functional reserve status in patients with hepatitis B （HB）. Methods 77 cases with HB were divided into two groups, hepatic function compensated group and hepatic function decompensated group. Plasma D-D, hepatic functional indexes and PT of all patients were detected. Results The level of D-D in the hepatic function decompensated group was higher than that in the hepatic function compensated group（ 299.0 ± 498.5 ） μg/L vs （ 27.9 ＋ 34.0）μg/L（ t = 3. 1,P 〈 0.01 ）. D-D negatively correlated with ALB and PA （ r = - 0.6, - 0.6, all P 〈 0.01 ）, and positively correla- ted with TBIL and PT（ r = 0.4,0.6, all P 〈 0.01 ）. Conclusion The level of plasma D-D related with hepatic func- tional reserve status, and detecting the level of D-D could be helpful to estimate hepatic functional reserve and progno- sis of patients with HB.
出处
《中国基层医药》
CAS
2011年第20期2762-2763,共2页
Chinese Journal of Primary Medicine and Pharmacy
