摘要
目的观察阿德福韦治疗HBeAg阴性慢性乙型肝炎患者HBV-DNA动态变化。方法选择HBeAg阴性慢性乙型肝炎患者58例,口服阿德福韦酯10mg,1次/d,分别于治疗4、8、12、24、36、48周时检测病毒载量及肝功,并进行数据统计分析。结果随着治疗时间的延长,发生病毒学应答的例数增多;治疗4、8、12、24、36周时各个阶段发生病毒学应答的患者于治疗48周时的完全应答率分别为100.0%、100.0%、94.7%、86.7%、81.6%和77.3%。结论阿德福韦能够快速降低HBeAg阴性慢性乙型肝炎患者,血清HBV-DNA和ALT水平,越早获得病毒学应答的患者,其最终获得完全应答的可能性越大。
OBJECTIVE To observe the treatment effect of adefovir in patients with HBeAg negative chronic hepatitis B.METHODS Fifty-eight cases of chronic hepatitis B with HBeAg negative were treated with adefovir 10mg per day orally and the course of treatment was 48 weeks.HBV-DNA and liver function were examined at 4,8,12,24 and 48 weeks.The data were recorded and analyzed.RESULTS As treatment time prolonged,more case happened viral response.The absolute response rates at 48 weeks in patients happening viral response at 4,8,12,24,36,48 weeks were 100.0%,100.0%,94.7%,86.7%,81.6% and 77.3%,respectively.CONCLUSION Adefovir can quickly reduce the serum level of HBV-DNA and ALT.The earlier the patients with HBeAg negative chronic hepatitis B get viral response,the more possible the absolute response will be acquired.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第18期3934-3935,共2页
Chinese Journal of Nosocomiology
