摘要
目的观察替米沙坦联合贝那普利对老年人高血压患者降压疗效和对糖、脂代谢的影响。方法 96例≥60岁的老年高血压患者,停用其他降压药物>2周,口服替米沙坦、贝那普利治疗8周,观察治疗第4周和第8周及治疗前的收缩压(SBP)、舒张压(DBP)、脉压差(PP)、24h动态血压、餐前血糖(FBS)、餐后2 h血糖(P2hBG)、餐前胰岛素(FINS)、餐后2 h胰岛素(P2hINS)、糖化血红蛋白(HbA1c)及血脂水平。结果与治疗前比较,替米沙坦联合贝那普利治疗4周患者SBP、DBP即有明显下降(P<0.05)。24 h平均血压、日间平均压和夜间平均压在治疗8周时下降显著(P<0.05)。治疗4周时患者三酰甘油(TG)、P2hBG、FINS、P2hINS、HbA1c明显降低(P<0.05),高密度脂蛋白胆固醇(HDL-C)明显升高(P<0.05)。治疗第8周低密度脂蛋白胆固醇(LDL-C)水平显著下降(P<0.05)。结论替米沙坦联合贝那普利除了有较好的降压效果外,还可以改善糖代谢和脂代谢,对于老年人高血压病患者尤其是糖、脂代谢紊乱者有较好的疗效。
Objective To investigate the therapeutic effects of telmisartan and benazepril in decreasing blood pressure and improving glucose,lipid metabolism in elderly patients with hypertension.Methods After two week withdrawal of anti hypertensive,96elderly patients with hypertension were given telmisartan 80 mg and benazepril 5mg for oral use.the levels of blood pressure,24 h ambulatory blood pressure and blood glucose and insulin,glycosylated hemoglobin,blood lipids were observed both before and 4,8 weeks after treatment.Results Telmisartan and benazepril decreased blood pressure after 4 weeks treatment（P0.05）.In comparison with prior treatment,the levels of blood glucose and plasma insulin,glycosylated hemoglobin,the serum triglyceride,LDL-C were decreased significantly,HDL-C was increased significantly（P0.05）.Conclusion Telmisartan and benazepril has good effects in decreasing blood pressure,and it also can improve glucose metabolism,lipid metabolism.it has a better therapeutic effect on elderly patients with hypertension especially the patients with metabolism disturbance.
出处
《临床合理用药杂志》
2011年第07X期12-13,15,共3页
Chinese Journal of Clinical Rational Drug Use
